Safety and Efficacy of Tafenoquine for Plasmodium vivax Malaria Prophylaxis and Radical Cure: Overview and Perspectives

This article is inter alia a brief, first-stop guide to possible adverse events (AEs) associated with tafenoquine (TQ) intake. Safety and efficacy findings for TQ in Plasmodium vivax malaria prophylaxis and radical cure are summarized and some of the latest TQ-related studies (published in 2020 and 2021) are highlighted. In addition, little-known biological and other matters concerning malaria parasites and 8-aminoquinoline (8-AQ) drug action are discussed and some correct terminology pertinent to malaria is explained.

Automated summary

This article serves as a brief guide on potential adverse events associated with tafenoquine (TQ) intake, summarizing safety and efficacy findings in Plasmodium vivax malaria prophylaxis and radical cure, and highlighting recent TQ-related studies. It also delves into lesser-known biological and other aspects of malaria parasites and 8-aminoquinoline (8-AQ) drug action, while providing explanations on relevant terminology in the field of malaria.