Organs-on-chip: The way forward

Review Biotechnology & Applied Microbiology

Organs-on-chips: into the next decade

Lucie A. Low et al.

Summary: OoCs, also known as microphysiological systems or 'tissue chips', have the potential to be informative at multiple stages of drug discovery and development, providing insights into normal human organ function and disease pathophysiology, as well as predicting the safety and efficacy of investigational drugs in humans. The field of OoCs has seen significant advances in recent years, but there are still challenges and opportunities that need to be addressed to fully realize their potential for translational research.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Biotechnology & Applied Microbiology

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

Nathalie Picollet-D'hahan et al.

Summary: Multiorgan-on-a-chip platforms have the potential to redefine human health research by providing comprehensive and personalized models for understanding and treating multisystem diseases. These models offer unique information that is not accessible with single-organ-on-a-chip models, but there are still challenges to overcome in realizing and adopting these platforms worldwide.

TRENDS IN BIOTECHNOLOGY (2021)

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Article Biochemical Research Methods

High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows†

H. Azizgolshani et al.

Summary: Drug development lacks predictive and human-relevant in vitro models. The Organ-on-chip (OOC) technology provides advanced culture capabilities to generate human-based tissue in vitro, but faces challenges in throughput and compatibility. This study presents an OOC platform with advanced culture capabilities supporting multiple human tissue models for drug screening and gene expression analysis.

LAB ON A CHIP (2021)

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Article Biochemical Research Methods

Accelerating innovation and commercialization through standardization of microfluidic-based medical devices

Darwin R. Reyes et al.

Summary: The microfluidics industry has seen steady growth, especially in the market for microfluidic medical devices, over the past few years. However, the lack of standards and guidelines within the microfluidics community has resulted in bottlenecks in the assessment of device performance.

LAB ON A CHIP (2021)

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Review Pharmacology & Pharmacy