Journal
STEM CELL REPORTS
Volume 16, Issue 6, Pages 1568-1583Publisher
CELL PRESS
DOI: 10.1016/j.stemcr.2021.04.015
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Funding
- National Natural Science Foundation of China [81772803, 81972479, 61627827, 62005085]
- Science and Technology Program of Guangzhou [2019050001]
- Scientific and Technological Planning Project of Guangzhou City [201904010038]
- Natural Science Foundation of Guangdong province [2019A1515011100, 2021A1515012576]
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Photobiomodulation therapy (PBMT) promotes hair regeneration by activating ll-CATENIN in hair follicle stem cells (HFSCs) through a synergistic mechanism involving reactive oxygen species (ROS) and WNT secretion from skin-derived precursors (SKPs).
Photobiomodulation therapy (PBMT) has shown encouraging results in the treatment of hair loss. However, the mechanism by which PBMT controls cell behavior to coordinate hair cycle is unclear. Here, PBMT is found to drive quiescent hair follicle stem cell (HFSC) activation and alleviate hair follicle atrophy. Mechanistically, PBMT triggers a new hair cycle by upregulating ll-CATENIN expression in HFSCs. Loss of bCatenin (Ctnnb1) in HFSCs blocked PBMT-induced hair regeneration. Additionally, we show PBMT-induced reactive oxygen species (ROS) activate the PI3K/AKT/GSK-3llsignaling pathway to inhibit proteasome degradation of ll-CATENIN in HFSCs. Furthermore, PBMT promotes the expression and secretion of WNTs in skin-derived precursors (SKPs) to further activate the ll-CATENIN signal in HFSCs. By contrast, eliminating ROS or inhibiting WNT secretion attenuates the activation of HFSCs triggered by PBMT. Collectively, our work suggests that PBMT promotes hair regeneration through synergetic activation of ll-CATENIN in HFSCs by ROS and paracrine WNTs by SKPs.
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