4.7 Review

Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances

Related references

Note: Only part of the references are listed.
Article Cell Biology

microRNA-21-5p from M2 macrophage-derived extracellular vesicles promotes the differentiation and activity of pancreatic cancer stem cells by mediating KLF3

Jian Chang et al.

Summary: This research demonstrates that M2 macrophage-derived exosomal miR-21-5p promotes differentiation and activity of PaCa stem cells by targeting KLF3. downregulation of miR-21-5p in M2 macrophage-derived EVs inhibits key cancer stem cell functions in vitro and tumor-forming ability in vivo.

CELL BIOLOGY AND TOXICOLOGY (2022)

Article Oncology

Emergence in protein derived nanomedicine as anticancer therapeutics: More than a tour de force

Zhenchang Wang et al.

Summary: Cancer is a major global health issue, with an expected increase in the number of patients to reach 420 million by 2025. Conventional treatment methods like surgery, chemotherapy, and radiation are being supplemented by advanced therapies like protein-based nano-medicines for targeted drug delivery to reduce side effects. These nanomedicines offer promising potential in revolutionizing cancer treatment.

SEMINARS IN CANCER BIOLOGY (2021)

Review Pharmacology & Pharmacy

Recent advances in drug delivery systems for targeting cancer stem cells

Hongxia Duan et al.

Summary: Cancer stem cells (CSCs) are a subpopulation of cancer cells with self-renewal and unlimited proliferation capabilities, playing a crucial role in tumor occurrence and development. Targeting CSCs has the potential to improve cancer therapy efficiency, with promising strategies such as targeting CSC niches, signaling pathways, and mitochondria under development. Advances in CSC-targeted drug delivery systems (DDSs) are being increasingly explored in the context of rapid progress in the field and nanotechnology.

ACTA PHARMACEUTICA SINICA B (2021)

Article Engineering, Biomedical

Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles

Eric Volta-Duran et al.

Summary: The study investigates the potential of conjugating tumor-targeted self-assembling protein nanoparticles with potent microbial toxins and chemically coupled chemotherapeutic drugs, resulting in multifunctional hybrid nanoconjugates with promising applications in oncology. The concept of drug combination proposed in this research could be a feasible strategy for enhancing the effectiveness of multiple drug treatments and overcoming acquired resistance in cancer therapy.

ACTA BIOMATERIALIA (2021)

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Chemistry, Multidisciplinary

Novel dendritic polyglycerol-conjugated, mesoporous silica-based targeting nanocarriers for co-delivery of doxorubicin and tariquidar to overcome multidrug resistance in breast cancer stem cells

Yuanwei Pan et al.

Summary: The study developed CSCs-specific targeted mSiO(2)-dPG nanocarriers for co-delivery of DOX and Tar, which significantly enhanced the chemotherapeutic efficacy against breast CSCs by suppressing stemness-associated gene expression and tumorspheres' formation ability.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

Targeted Delivery of Combination Therapeutics Using Monoclonal Antibody 2C5-Modified Immunoliposomes for Cancer Therapy

Radhika Narayanaswamy et al.

Summary: The study successfully developed immunoliposomes modified with a cancer-specific antibody and co-loaded with two chemotherapeutics to inhibit cancer cell proliferation and achieve targeted therapy. The experimental results confirmed the effectiveness and safety of this approach through a series of in vitro and ex vivo studies.

PHARMACEUTICAL RESEARCH (2021)

Article Materials Science, Multidisciplinary

Controlling self-assembling and tumor cell-targeting of protein-only nanoparticles through modular protein engineering

Eric Volta-Duran et al.

SCIENCE CHINA-MATERIALS (2020)

Article Oncology

Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

Elham Masoumi et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Review Pharmacology & Pharmacy

Cancer stem cells and nanomedicine: new opportunities to combat multidrug resistance?

Alessandro Dalpiaz et al.

DRUG DISCOVERY TODAY (2020)

Article Chemistry, Multidisciplinary

A self-assembly and stimuli-responsive fusion gelonin delivery system for tumor treatment

Quan Liu et al.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Antibody-Drug Conjugates for Cancer Therapy

Umbreen Hafeez et al.

MOLECULES (2020)

Review Biotechnology & Applied Microbiology

The potential of nanomedicine to alter cancer stem cell dynamics: the impact of extracellular vesicles

Petra Gener et al.

NANOMEDICINE (2020)

Review Pharmacology & Pharmacy

Extracellular Vesicles as Drug Delivery Systems in Cancer

Laia Hernandez-Oller et al.

PHARMACEUTICS (2020)

Review Materials Science, Multidisciplinary

Recent developments of mesoporous silica nanoparticles in biomedicine

Liang Chen et al.

EMERGENT MATERIALS (2020)

Review Chemistry, Multidisciplinary

Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles

Manali Haniti Mohd-Zahid et al.

RSC ADVANCES (2020)

Review Nanoscience & Nanotechnology

Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives

Anubhab Mukherjee et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Biochemistry & Molecular Biology

Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways

Zhangjun Cheng et al.

MOLECULAR CARCINOGENESIS (2019)

Article Medicine, Research & Experimental

Salinomycin-Loaded Gold Nanoparticles for Treating Cancer Stem Cells by Ferroptosis-Induced Cell Death

Yongmei Zhao et al.

MOLECULAR PHARMACEUTICS (2019)

Article Chemistry, Multidisciplinary

Integrating Nanotechnology into Cancer Care

Piotr Grodzinski et al.

ACS NANO (2019)

Review Cell Biology

Diverse Cellular Roles of Autophagy

Hideaki Morishita et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35 (2019)

Article Medicine, Research & Experimental

The promotion of nanoparticle delivery to two populations of gastric cancer stem cells by CD133 and CD44 antibodies

Han Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Cell Biology

Extracellular vesicles in type 2 diabetes mellitus: key roles in pathogenesis, complications, and therapy

Yongwei Xiao et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

Article Cell & Tissue Engineering

Carrier-Free CXCR4-Targeted Nanoplexes Designed for Polarizing Macrophages to Suppress Tumor Growth

Michael B. Deci et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2019)

Article Pharmacology & Pharmacy

Protein-driven nanomedicines in oncotherapy

Soida Casanova et al.

CURRENT OPINION IN PHARMACOLOGY (2019)

Article Nanoscience & Nanotechnology

CD44-Targeted Magnetic Nanoparticles Kill Head And Neck Squamous Cell Carcinoma Stem Cells In An Alternating Magnetic Field

Zhan Su et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Editorial Material Oncology

Antibody Drug Conjugates for Cancer Treatment

Christine M. Walko et al.

JAMA ONCOLOGY (2019)

Article Nanoscience & Nanotechnology

Co-Delivery of Docetaxel and Salinomycin to Target Both Breast Cancer Cells and Stem Cells by PLGA/TPGS Nanoparticles

Jie Gao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Multidisciplinary Sciences

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Tuying Yong et al.

NATURE COMMUNICATIONS (2019)

Article Materials Science, Multidisciplinary

Self-assembling nanoparticles biofunctionalized with magnetite-binding protein for the targeted delivery to HER2/neu overexpressing cancer cells

Victoria O. Shipunova et al.

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS (2019)

Article Materials Science, Biomaterials

The feasibility of ROS- and GSH-responsive micelles for treating tumor-initiating and metastatic cancer stem cells

Lu-Yi Yu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

Review Cell & Tissue Engineering

Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review

Fatemeh Asghari et al.

INTERNATIONAL JOURNAL OF STEM CELLS (2019)

Review Pharmacology & Pharmacy

Recent advances in metal nanoparticles in cancer therapy

Ankush Sharma et al.

JOURNAL OF DRUG TARGETING (2018)

Review Biochemistry & Molecular Biology

Nanotechnology for Cancer Therapy Based on Chemotherapy

Chen-Yang Zhao et al.

MOLECULES (2018)

Review Biotechnology & Applied Microbiology

Magnetic iron oxide nanoparticles as drug carriers: preparation, conjugation and delivery

Kheireddine El-Boubbou

NANOMEDICINE (2018)

Review Biotechnology & Applied Microbiology

Protein-Based Therapeutic Killing for Cancer Therapies

Naroa Serna et al.

TRENDS IN BIOTECHNOLOGY (2018)

Review Pharmacology & Pharmacy

Mesoporous silica nanoparticles for drug and gene delivery

Yixian Zhou et al.

ACTA PHARMACEUTICA SINICA B (2018)

Article Nanoscience & Nanotechnology

Novel silk fibroin nanoparticles incorporated silk fibroin hydrogel for inhibition of cancer stem cells and tumor growth

Puyuan Wu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Review Chemistry, Multidisciplinary

Cancer stem cells-emanated therapy resistance: Implications for liposomal drug delivery systems

Hassan Dianat-Moghadam et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Cell & Tissue Engineering

Novel Insights into Adult and Cancer Stem Cell Biology

Deepa Bhartiya et al.

STEM CELLS AND DEVELOPMENT (2018)

Review Cell Biology

Nanomedicine in cancer stem cell therapy: from fringe to forefront

Nazish Tabassum et al.

CELL AND TISSUE RESEARCH (2018)

Review Biochemistry & Molecular Biology

Targeting Cancer Stem Cells to Overcome Chemoresistance

Toni Nunes et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biotechnology & Applied Microbiology

Specific cancer stem cell-therapy by albumin nanoparticles functionalized with CD44-mediated targeting

Yuanyuan Li et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

Article Biotechnology & Applied Microbiology

Comparison study of the effect of alkyl-modified and unmodified PAMAM and PPI dendrimers on solubility and antitumor activity of crocetin

Fatemeh Soltani et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)

Article Biochemistry & Molecular Biology

Novel Nano-Therapeutic Approach Actively Targets Human Ovarian Cancer Stem Cells after Xenograft into Nude Mice

Amoura Abou-ElNaga et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Pharmacology & Pharmacy

Advantages of Drug Selective Distribution in Cancer Treatment: Brentuximab Vedotin

Luis Mario Villela-Martinez et al.

INTERNATIONAL JOURNAL OF PHARMACOLOGY (2017)

Review Chemistry, Multidisciplinary

Nano-delivery system targeting to cancer stem cell cluster of differentiation biomarkers

Ahad Mokhtarzadeh et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Chemistry, Multidisciplinary

Biodegradable nano-polymers as delivery vehicles for therapeutic small non-coding ribonucleic acids

Ahad Mokhtarzadeh et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Editorial Material Materials Science, Multidisciplinary

Taking the vehicle out of drug delivery

Jianliang Shen et al.

MATERIALS TODAY (2017)

Article Nanoscience & Nanotechnology

Combination therapy of paclitaxel and cyclopamine polymer-drug conjugates to treat advanced prostate cancer

Ruinan Yang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

Review Oncology

Mitochondrial biology in cancer stem cells

Rute Loureiro et al.

SEMINARS IN CANCER BIOLOGY (2017)

Article Multidisciplinary Sciences

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

Haiyang Zhang et al.

NATURE COMMUNICATIONS (2017)

Review Cell & Tissue Engineering

Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications

Eunice Yuen-Ting Lau et al.

STEM CELLS INTERNATIONAL (2017)

Review Pharmacology & Pharmacy

Exosome-Based Cancer Therapy: Implication for Targeting Cancer Stem Cells

Jinheng Wang et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

Weiwei Qin et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Drug-Loaded Polymeric Nanoparticles for Cancer Stem Cell Targeting

Binbin Li et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Nanoscience & Nanotechnology

Targeting Colorectal Cancer Stem-Like Cells with Anti-CD133 Antibody-Conjugated SN-38 Nanoparticles

Sin-Tzu Ning et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Review Biotechnology & Applied Microbiology

Recent advances on biocompatible and biodegradable nanoparticles as gene carriers

Ahad Mokhtarzadeh et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2016)

Article Nanoscience & Nanotechnology

A novel double-targeted nondrug delivery system for targeting cancer stem cells

Shupei Qiao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

Article Pharmacology & Pharmacy

Gold nanoparticles enhance 5-fluorouracil anticancer efficacy against colorectal cancer cells

Mohamed A. Safwat et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Review Chemistry, Analytical

Aptamers as smart ligands for nano-carriers targeting

Ahad Mokhtarzadeh et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2016)

Article Materials Science, Multidisciplinary

Evaluation of nanomedicines: stick to the basics

Scott E. McNeil

Nature Reviews Materials (2016)

Review Chemistry, Multidisciplinary

New trends in guided nanotherapies for digestive cancers: A systematic review

Elisabete Fernandes et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Nanoscience & Nanotechnology

Anthothecol-encapsulated PLGA nanoparticles inhibit pancreatic cancer stem cell growth by modulating sonic hedgehog pathway

Raj Kumar Verma et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

Review Chemistry, Multidisciplinary

Antibody- Drug Conjugates: An Emerging Concept in Cancer Therapy

Ravi V. J. Chari et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Biochemistry & Molecular Biology

Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro

Tyson J. Smyth et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

Article Medicine, Research & Experimental

Enhanced Photodynamic Therapy and Effective Elimination of Cancer Stem Cells Using Surfactant-Polymer Nanoparticles

Marina Usacheva et al.

MOLECULAR PHARMACEUTICS (2014)

Review Pharmacology & Pharmacy

Role of integrated cancer nanomedicine in overcoming drug resistance

Arun K. Iyer et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Article Chemistry, Physical

Fabrication and functional characterization of goldnanoconjugates for potential application in ovarian cancer

Chitta Ranjan Patra et al.

JOURNAL OF MATERIALS CHEMISTRY (2010)

Article Multidisciplinary Sciences

Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity

Nripen Chanda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Chemistry, Multidisciplinary

Gold Nanoparticles in Biology: Beyond Toxicity to Cellular Imaging

Catherine J. Murphy et al.

ACCOUNTS OF CHEMICAL RESEARCH (2008)

Article Gastroenterology & Hepatology

Identification of local and circulating cancer stem cells in human liver cancer

Zhen Fan Yang et al.

HEPATOLOGY (2008)

Article Multidisciplinary Sciences

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

M. E. Prince et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Catherine A. O'Brien et al.

NATURE (2007)

Article Multidisciplinary Sciences

Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness

Paul P. Szotek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Oncology

Prostate cancer stem cells

Anne T. Collins et al.

EUROPEAN JOURNAL OF CANCER (2006)

Article Biochemistry & Molecular Biology

Identification of bronchioalveolar stem cells in normal lung and lung cancer

CFB Kim et al.

Article Multidisciplinary Sciences

Cancerous stem cells can arise from pediatric brain tumors

HD Hemmati et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Prospective identification of tumorigenic breast cancer cells

M Al-Hajj et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)