Journal
NANOMATERIALS
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/nano11061546
Keywords
core-shell nanofiber; drug delivery; co-axial centrifugal spinning; wound healing
Categories
Funding
- Science and Technology Program of Hubei Province [2019AEE011, 2018AAA036]
- National Natural Science Foundation of China [51175385]
- Central Public-Interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences [1630122017009, 1630122017010]
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Core-shell nanofibers show great potential for biomedical applications like wound healing, enabling easier control of drug release profile. Co-axial centrifugal spinning is an efficient method to produce core-shell nanofibers, addressing the challenge of high production rate with low energy consumption.
Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.
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