Journal
MULTIPLE SCLEROSIS AND RELATED DISORDERS
Volume 51, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.msard.2021.102910
Keywords
Multiple Sclerosis; Optic Neuritis; Body Mass Index; Leptin; Sex Hormones; Relapse Recovery
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Funding
- U.S. Department of Defense [W81XWH-18-1-0648]
- John F. Sparks Memorial Studentship Fund, Queens University
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Analysis of 61 patients with multiple sclerosis showed that higher BMI, serum estrogen levels, and serum leptin levels were associated with the severity of AON in male patients but not in female patients. No association was found between these factors and AON recovery.
Background: Obesity is an important modifiable risk factor of MS; a deeper biological understanding of this association is needed. Objective: To evaluate the determinants of acute optic neuritis (AON) severity and recovery in multiple sclerosis (MS). Methods: We included 61 patients with MS with recorded AON severity and recovery according to visual acuity outcomes before, at, and, after the relapse. We measured body mass index (BMI) and the serum concentration of estrogen, leptin, testosterone, sex hormone-binding globulin, and vitamin D. We tested the association between BMI and serum hormones and AON severity and recovery with logistic regressions. Results: In males, moderate/severe AON was associated with higher BMI (31.26 kg/m2 vs 25.73 kg/m2, logistic regression, p= 0.03), higher serum estrogen levels (32.24 nmol/L vs 23.06 nmol/L, logistic regression, p=0.04), and higher serum leptin levels (12.29 ng/mL vs mild AON: 4.1 ng/mL, logistic regression, p=0.06) than mild AON. These observations were not seen in female patients. We did not find an association with BMI or hormone levels and AON recovery. Conclusion: BMI, serum leptin, and serum estrogen were associated with AON severity in male patients but not in female patients. No association of these factors and AON recovery was observed.
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