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The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds

Journal

MOLECULAR THERAPY-NUCLEIC ACIDS
Volume 24, Issue -, Pages 554-578

Publisher

CELL PRESS
DOI: 10.1016/j.omtn.2021.03.015

Keywords

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Funding

  1. National Natural Science Foundation of China [80660323, 81801921]

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This article discusses the role and challenges of non-coding RNA in chronic diabetic wounds, providing insights into new diagnostic and treatment strategies.
Chronic diabetic wounds affect the quality of life of patients, resulting in significant social and economic burdens on both individuals and the health care system. Although treatment methods for chronic diabetic wounds have been explored, there remains a lack of effective treatment strategies; therefore, alternative strategies must be explored. Recently, the abnormal expression of non-coding RNA in diabetic wounds has received widespread attention since it is an important factor in the development of diabetic wounds. This article reviews the regulatory role of three common non-coding RNAs (microRNA [miRNA], long non-coding RNA [lncRNA], and circular RNA [circRNA]) in diabetic wounds and discusses the diagnosis, treatment potential, and challenges of non-coding RNA in diabetic wounds. This article provides insights into new strategies for diabetic wound diagnosis and treatment at the genetic and molecular levels.

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