Journal
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Volume 44, Issue 12, Pages 2741-2748Publisher
SPRINGER
DOI: 10.1007/s40618-021-01602-8
Keywords
Glycemia; Fasting; Postprandial; Obesity; Sleep apnea
Categories
Funding
- Universita degli Studi di Bari Aldo Moro within the CRUI-CARE Agreement
Ask authors/readers for more resources
OSA is often underdiagnosed in patients with type 2 diabetes, and this study found a significant relationship between OSA and glycometabolic parameters in obese non-diabetic subjects. High values of 2 h-PG and HbA1c may indicate the presence of OSA in obese individuals, beyond traditional clinical parameters.
Introduction Obstructive sleep apnoea (OSA) is an underdiagnosed condition frequently associated with glycaemic control impairment in patients with type 2 diabetes. Aim To assess the relationship between glycometabolic parameters and OSA in obese non-diabetic subjects. Methods Ninety consecutive subjects (mean age 44.9 +/- 12 years, mean BMI 42.1 +/- 9 kg/m(2)) underwent polysomnography and a 2-h oral glucose tolerance test (OGTT). Results OSA was identified in 75% of subjects, with a higher prevalence of males compared to the group of subjects without OSA (62% vs 32%, p = 0.02). Patients with OSA had comparable BMI (42.8 kg/m(2) vs 39.4 kg/m(2)), a higher average HbA1c (5.8% vs 5.4%, p < 0.001), plasma glucose at 120 min during OGTT (2 h-PG; 123 mg/dl vs 97 mg/dl, p = 0.009) and diastolic blood pressure (81.1 mmHg vs 76.2 mmHg, p = 0.046) than obese subjects without OSA. HbA1c and 2 h-PG were found to be correlated with the apnoea-hypopnoea index (AHI; r = 0.35 and r = 0.42, respectively) and with percent of sleep time with oxyhaemoglobin saturation < 90% (ST90; r = 0.44 and r = 0.39, respectively). Further, in a linear regression model, ST90 and AHI were found to be the main determinants of 2 h-PG (beta = 0.81, p < 0.01 and beta = 0.75, p = 0.02, respectively) after controlling for age, sex, waist circumference, physical activity, and C-reactive protein. Similarly, ST90 and AHI persisted as independent determinants of HbA1c (beta = 0.01, p = 0.01 and beta = 0.01, p = 0.01, respectively). Conclusion Beyond the traditional clinical parameters, the presence of a normal-high value of 2 h-PG and HbA1c should raise suspicion of the presence of OSA in obese subjects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available