Journal
GENES
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/genes12070970
Keywords
long non-coding RNAs; preeclampsia; intrauterine growth restriction
Categories
Funding
- ANID/CONICYT-FONDECYT de Iniciacion [11190998, 11181249]
- ANID/CONICYT-FONDECYT [1201851, 3160622]
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PE and IUGR are two prevalent pregnancy-specific placental disorders with high morbidity and mortality rates, and lncRNAs play a crucial role in regulating trophoblasts during the development of these diseases.
Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.
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