Journal
GENES
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/genes12071012
Keywords
erythroid differentiation; 3D genomics; TADs; chromatin organization
Categories
Funding
- Russian Foundation for Basic Research [19-34-90096]
- Ministry of Education and Science of Russian Federation [2019-0546 (FSUS-2020-0040)]
- Institute of Cytology and Ge-netics [0259-2021-0016]
Ask authors/readers for more resources
Hematopoiesis serves as a convenient model to study how chromatin dynamics regulate cell fate. The interaction between transcription factors and epigenetic modifiers leads to silencing of multipotent transcriptome and activation of transcriptional program for terminal differentiation.
Hematopoiesis is a convenient model to study how chromatin dynamics plays a decisive role in regulation of cell fate. During erythropoiesis a population of stem and progenitor cells becomes increasingly lineage restricted, giving rise to terminally differentiated progeny. The concerted action of transcription factors and epigenetic modifiers leads to a silencing of the multipotent transcriptome and activation of the transcriptional program that controls terminal differentiation. This article reviews some aspects of the biology of red blood cells production with the focus on the extensive chromatin reorganization during differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available