Journal
GENES
Volume 12, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/genes12060856
Keywords
microRNA; subcellular localization; transcriptional regulation; phase separation; condensate
Categories
Funding
- Clarendon Fund, UK [SFF1920_CB_MSD_759707]
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZYYC20001]
- National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University [Z20191011]
- National Key Research and Development Program of China [2018YFA0108302]
- National Natural Science Foundation of China [82070594, 32090043, 31771505]
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miRNAs are believed to play a role as post-transcriptional regulators in the cytoplasm, affecting transcription and cellular homeostasis through their subcellular localization. Recent studies have revealed novel insights into the unconventional functions and mechanisms of miRNAs at the transcriptional and post-transcriptional levels.
MicroRNAs (miRNAs) are thought to act as post-transcriptional regulators in the cytoplasm by either dampening translation or stimulating degradation of target mRNAs. With the increasing resolution and scope of RNA mapping, recent studies have revealed novel insights into the subcellular localization of miRNAs. Based on miRNA subcellular localization, unconventional functions and mechanisms at the transcriptional and post-transcriptional levels have been identified. This minireview provides an overview of the subcellular localization of miRNAs and the mechanisms by which they regulate transcription and cellular homeostasis in mammals, with a particular focus on the roles of phase-separated biomolecular condensates.
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