4.7 Review

Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma

Related references

Note: Only part of the references are listed.
Review Oncology

Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches

Md Sahab Uddin et al.

Summary: Research has shown that glioma progression is closely linked to different types of epigenetic phenomena, such as chromatin modifications, DNA methylation, chromatin remodeling, and aberrant microRNA. Targeting the genes and proteins that control these alterations can be an effective way to treat GBM. Treatment approaches include histone deacetylase inhibitors and DNA methyltransferase inhibitors.

SEMINARS IN CANCER BIOLOGY (2022)

Review Pharmacology & Pharmacy

Fascinating Chemopreventive Story of Wogonin: A Chance to Hit on the Head in Cancer Treatment

Rajesh Kumar et al.

Summary: Cancer, a global havoc, is difficult to control due to limited effective therapies. Wogonin, a natural product extracted from Scutellaria baicalensis, has been widely studied for its potential to tackle cancer through various mechanisms, making it a promising candidate for cancer treatment.

CURRENT PHARMACEUTICAL DESIGN (2021)

Review Pharmacology & Pharmacy

Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-kappa B to Halt Alzheimer's Disease

Md Sahab Uddin et al.

Summary: Alzheimer's disease is a chronic brain disorder with no exact remedies currently available. Neuroinflammation plays a crucial role in AD pathogenesis, with NF-kappa B showing promise as a candidate for inflammation-based therapy. Phytochemicals, particularly polyphenols, exhibit neuroprotective functions and may interfere with NF-kappa B signaling pathway to potentially combat AD.

CURRENT PHARMACEUTICAL DESIGN (2021)

Review Medicine, Research & Experimental

Polyphenolic molecules targeting STAT3 pathway for the treatment of cancer

Md Abdul Aziz et al.

Summary: Studies have shown that polyphenolic compounds have preventive and protective effects against cancer, primarily by targeting the STAT3 signaling pathway. These polyphenols exert their effects by inhibiting the activation and phosphorylation of STAT3, thereby blocking cell proliferation, metastasis, and drug resistance.

LIFE SCIENCES (2021)

Review Chemistry, Medicinal

Natural Products in Cancer Therapy: Past, Present and Future

Min Huang et al.

Summary: Natural products have been extensively studied for their anticancer potential for over half a century, leading to significant advancements in clinical use and therapeutic opportunities. However, challenges remain as the landscape of cancer therapy evolves and cutting-edge technologies play an increasing role. It is crucial to revisit and explore strategies for understanding and utilizing natural products in cancer therapy.

NATURAL PRODUCTS AND BIOPROSPECTING (2021)

Review Pharmacology & Pharmacy

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Shian-Ren Lin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Review Environmental Sciences

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

Md. Sahab Uddin et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Plant Sciences

Curcumin potentiates the antitumor activity of Paclitaxel in rat glioma C6 cells

Deborah Fratantonio et al.

PHYTOMEDICINE (2019)

Review Medicine, Research & Experimental

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

Elizabeta Zaplatic et al.

LIFE SCIENCES (2019)

Review Biochemistry & Molecular Biology

The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism

Marjorie Reyes-Farias et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

The Potential Use of Resveratrol for Cancer Prevention

Dominique Vervandier-Fasseur et al.

MOLECULES (2019)

Review Food Science & Technology

Vascular endothelial growth factor: An important molecular target of curcumin

Maryann Saberi-Karimian et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

Review Biochemistry & Molecular Biology

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

Melina Mitsiogianni et al.

ANTIOXIDANTS (2019)

Article Oncology

Baicalein induces cervical cancer apoptosis through the NF-B signaling pathway

Xiaolan Yu et al.

MOLECULAR MEDICINE REPORTS (2018)

Review Immunology

NF-κB, inflammation, immunity and cancer: coming of age

Koji Taniguchi et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling

Lalita Subedi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biotechnology & Applied Microbiology

Low concentration of quercetin antagonizes the invasion and angiogenesis of human glioblastoma U251 cells

Yue Liu et al.

ONCOTARGETS AND THERAPY (2017)

Review Biochemistry & Molecular Biology

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

Xiaohui Yan et al.

CELL AND BIOSCIENCE (2017)

Article Medicine, Research & Experimental

Effects of quercetin on proliferation and migration of human glioblastoma U251 cells

Yue Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Editorial Material Oncology

The role of NF-kappa B in modulating antitumor immunity

Ann Richmond et al.

ONCOIMMUNOLOGY (2016)

Article Pharmacology & Pharmacy

Quercetin derivative induces cell death in glioma cells by modulating NF-κB nuclear translocation and caspase-3 activation

Cintia J. Kiekow et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

Review Multidisciplinary Sciences

Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants

Qing Zhao et al.

SCIENCE BULLETIN (2016)

Article Multidisciplinary Sciences

Targeting NF-kappa B in glioblastoma: A therapeutic approach

Dinorah Friedmann-Morvinski et al.

SCIENCE ADVANCES (2016)

Review Biochemistry & Molecular Biology

The Fascinating Effects of Baicalein on Cancer: A Review

Hui Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Biochemistry & Molecular Biology

Protective effect of apigenin on Freund's complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway

Xiayun Chang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2015)

Review Chemistry, Medicinal

Novel NF-κB inhibitors: a patent review (2011-2014)

Sateesh Kumar Arepalli et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2015)

Article Oncology

NF-κB, an Active Player in Human Cancers

Yifeng Xia et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Review Oncology

The role of NF-kappa B in the pathogenesis of glioma

Vineshkumar Thidil Puliyappadamba et al.

MOLECULAR & CELLULAR ONCOLOGY (2014)

Article Biochemistry & Molecular Biology

Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres

Monica Patane et al.

MOLECULAR CANCER (2013)

Article Oncology

Inhibition of NF-κB Signaling Ablates the Invasive Phenotype of Glioblastoma

Mike-Andrew Westhoff et al.

MOLECULAR CANCER RESEARCH (2013)

Article Multidisciplinary Sciences

NF-κB-Induced IL-6 Ensures STAT3 Activation and Tumor Aggressiveness in Glioblastoma

Braden C. McFarland et al.

PLOS ONE (2013)

Review Multidisciplinary Sciences

Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone

Azhar Rasul et al.

SCIENTIFIC WORLD JOURNAL (2013)

Article Multidisciplinary Sciences

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65

Tiejun Zhang et al.

NATURE COMMUNICATIONS (2013)

Article Cell Biology

Opposing Effect of EGFRWT on EGFRvIII-Mediated NF-κB Activation with RIP1 as a Cell Death Switch

Vineshkumar Thidil Puliyappadamba et al.

CELL REPORTS (2013)

Article Medicine, Research & Experimental

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

Libing Song et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Biochemistry & Molecular Biology

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

R. Bonavia et al.

ONCOGENE (2012)

Article Multidisciplinary Sciences

Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB network

Kristen M. Holmes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Rheumatology

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

Sergei I. Grivennikov et al.

ANNALS OF THE RHEUMATIC DISEASES (2011)

Article Biochemistry & Molecular Biology

Quercetin-induced downregulation of phospholipase D-1 inhibits proliferation and invasion in U87 glioma cells

Mi Hee Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Review Cell Biology

Non-canonical NF-kappa B signaling pathway

Shao-Cong Sun

CELL RESEARCH (2011)

Article Neurosciences

MicroRNAs in Brain Tumors

Richard Hummel et al.

MOLECULAR NEUROBIOLOGY (2011)

Article Multidisciplinary Sciences

A Ten-microRNA Expression Signature Predicts Survival in Glioblastoma

Sujaya Srinivasan et al.

PLOS ONE (2011)

Article Oncology

The NFκB pathway: a therapeutic target in glioblastoma

Lorena Nogueira et al.

ONCOTARGET (2011)

Article Toxicology

Inhibition of p65 Nuclear Translocation by Baicalein

Min Bum Seo et al.

TOXICOLOGICAL RESEARCH (2011)

Article Pharmacology & Pharmacy

The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo

Dario Brunelli et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Review Biochemistry & Molecular Biology

Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy

Feng Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2010)

Article Mathematical & Computational Biology

Minimally perturbing a gene regulatory network to avoid a disease phenotype: the glioma network as a test case

Guy Karlebach et al.

BMC SYSTEMS BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

Sergei I. Grivennikov et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2010)

Review Clinical Neurology

NF-κB and STAT3 signaling in glioma: targets for future therapies

George P. Atkinson et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2010)

Article Engineering, Biomedical

An Integrative Approach for In Silico Glioma Research

Lee A. D. Cooper et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2010)

Article Oncology

Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma

Surasak Phuphanich et al.

JOURNAL OF NEURO-ONCOLOGY (2010)

Article Biochemistry & Molecular Biology

Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth

Anita B. Hjelmeland et al.

PLOS BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Anti-NF-κB and anti-inflammatory activities of synthetic isothiocyanates: Effect of chemical structures and cellular signaling

Auemduan Prawan et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2009)

Review Oncology

Multi-targeted prevention of cancer by sulforaphane

John D. Clarke et al.

CANCER LETTERS (2008)

Article Oncology

MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells

Thales Papagiannakopoulos et al.

CANCER RESEARCH (2008)

Article Pharmacology & Pharmacy

Parthenolide induces apoptosis in glioblastomas without affecting NF-κB

Krystal N. Anderson et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2008)

Review Neurosciences

Glioma stem cells: A midterm exam

Charles D. Stiles et al.

NEURON (2008)

Review Cell Biology

Malignant astrocytic glioma: genetics, biology, and paths to treatment

Frank B. Furnari et al.

GENES & DEVELOPMENT (2007)

Article Biochemistry & Molecular Biology

Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFκB transcription factors

Krishnan M. Dhandapani et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Introduction to NF-κB:: players, pathways, perspectives

T. D. Gilmore

ONCOGENE (2006)

Review Oncology

Mechanisms of angiogenesis in gliomas

O. Kargiotis et al.

JOURNAL OF NEURO-ONCOLOGY (2006)

Article Biochemistry & Molecular Biology

Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells

SY Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Biochemistry & Molecular Biology

Extensive modulation of a set of microRNAs in primary glioblastoma

SA Ciafrè et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Pathology

NF-kB in development and progression of human cancer

X Dolcet et al.

VIRCHOWS ARCHIV (2005)