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Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

Journal

FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.687935

Keywords

medicinal plants; neuroprotection; mitochondria; neurodegeneration; centella asiatica (L; ) Urb; antioxidative; mitoprotective

Funding

  1. Nanyang Technological University Singapore
  2. NKEA Research Grant Scheme (NRGS) [NH1014D049]

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Centella asiatica, a medicinal plant, has demonstrated anti-inflammatory, neuroprotective, and cognitive benefits which may be harnessed for treating brain aging and neurodegenerative diseases by its mitoprotective and antioxidative effects.
Natural products remain a crucial source of drug discovery for accessible and affordable solutions for healthy aging. Centella asiatica (L.) Urb. (CA) is an important medicinal plant with a wide range of ethnomedicinal uses. Past in vivo and in vitro studies have shown that the plant extract and its key components, such as asiatic acid, asiaticoside, madecassic acid and madecassoside, exhibit a range of anti-inflammatory, neuroprotective, and cognitive benefits mechanistically linked to mitoprotective and antioxidant properties of the plant. Mitochondrial dysfunction and oxidative stress are key drivers of aging and neurodegenerative disease, including Alzheimer's disease and Parkinson's disease. Here we appraise the growing body of evidence that the mitoprotective and antioxidative effects of CA may potentially be harnessed for the treatment of brain aging and neurodegenerative disease.

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