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Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma

Journal

FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.750857

Keywords

glioma; glioma stem cells; microenvironment; immune suppression; treatment

Funding

  1. Liaoning Provincial Natural Science Foundation of China [2019-BS-056]
  2. Science and Technology Innovation Fund Project of Dalian [2021JJ13SN55]
  3. Youth Scientific Research guiding Project of Fujian Provincial Health Commission [2018-ZQN-80]

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Glioma stem cells play a crucial role in the immune microenvironment of glioma, becoming a focus of research. Immunotherapeutic strategies targeting glioma stem cells have gained increasing attention, providing new perspectives for the immunotherapy of glioma.
Gliomas are the most common primary tumors of the central nervous system. Due to the existence of the blood-brain barrier and its unique regional immune characteristics, the study of the immune microenvironment of gliomas is particularly important. Glioma stem cells are an important cause of initiating glioma, promoting tumor progression and leading to tumor recurrence. Immunotherapeutic strategies targeting glioma stem cells have become the focus of current research. This paper will focus on the research progress of glioma stem cells in the immune microenvironment of glioma to provide the basis for the immunotherapy of glioma.

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