4.7 Review

New Developments in Prokinetic Therapy for Gastric Motility Disorders

Related references

Note: Only part of the references are listed.
Article Nutrition & Dietetics

Blinded, Double-Dummy, Parallel-Group, Phase 2a Randomized Clinical Trial to Evaluate the Efficacy and Safety of a Highly Selective 5-Hydroxytryptamine Type 4 Receptor Agonist in Critically Ill Patients With Enteral Feeding Intolerance

Marianne J. Chapman et al.

Summary: This study compared the efficacy of TAK-954 and metoclopramide in treating EFI in critically ill patients, finding that a single dose of TAK-954 appears to have similar efficacy in accelerating gastric emptying to multiple doses of metoclopramide without increased adverse events.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2021)

Article Gastroenterology & Hepatology

Efficacy and Safety of Tradipitant in Patients With Diabetic and Idiopathic Gastroparesis in a Randomized, Placebo-Controlled Trial

Jesse L. Carlin et al.

Summary: The study investigated the safety and efficacy of NK1R antagonist tradipitant in patients with idiopathic or diabetic gastroparesis, showing significant improvements in nausea symptoms and increased nausea-free days in patients treated with tradipitant compared to placebo.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Gastric accommodation influences proximal gastric and total gastric emptying in concurrent measurements conducted in healthy volunteers

Xiao Jing Wang et al.

Summary: This study found that postprandial gastric accommodation is significantly associated with the rate of gastric emptying, with higher gastric volumes leading to prolongation of emptying. The study also introduced novel methods to measure proximal gastric accommodation and correct for radioisotope upscatter.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

Article Gastroenterology & Hepatology

Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK-906), a dopamine D2/D3 receptor antagonist, in patients with gastroparesis

Braden Kuo et al.

Summary: This study evaluated the safety, pharmacokinetics, and pharmacodynamics of twice-daily trazpiroben in patients with gastroparesis, demonstrating favorable tolerability and safety with potential benefits for the treatment of gastroparesis.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Article Gastroenterology & Hepatology

Velusetrag accelerates gastric emptying in subjects with gastroparesis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 study

Braden Kuo et al.

Summary: The study aimed to evaluate the efficacy and safety of velusetrag in accelerating gastric emptying in patients with diabetic or idiopathic gastroparesis. Results showed that treatment with velusetrag significantly increased gastric emptying rates in the subjects, with similar efficacy observed in both diabetic and idiopathic gastroparesis patients.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Article Gastroenterology & Hepatology

Randomised study: effects of the 5-HT4 receptor agonist felcisetrag vs placebo on gut transit in patients with gastroparesis

Victor Chedid et al.

Summary: The study evaluated the pharmacokinetics and pharmacodynamics of the highly selective 5-HT4 receptor agonist felcisetrag in patients with gastroparesis, and found that felcisetrag significantly accelerated gastric emptying and colonic transit while being well tolerated.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Article Gastroenterology & Hepatology

Overall safety of relamorelin in adults with diabetic gastroparesis: Analysis of phase 2a and 2b trial data

Michael Camilleri et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

Editorial Material Gastroenterology & Hepatology

Opiates, the Pylorus, and Gastroparesis

Michael Camilleri et al.

GASTROENTEROLOGY (2020)

Review Gastroenterology & Hepatology

Effects of Promotility Agents on Gastric Emptying and Symptoms: A Systematic Review and Meta-analysis

Priya Vijayvargiya et al.

GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study

Florencia Carbone et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis

William L. Hasler et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Enhanced Gastric Emptying Scintigraphy to Assess Fundic Accommodation Using Intragastric Meal Distribution and Antral Contractility

Perry Orthey et al.

JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY (2019)

Article Gastroenterology & Hepatology

Idiopathic gastroparesis is associated with specific transcriptional changes in the gastric muscularis externa

B. P. Herring et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2018)

Article Gastroenterology & Hepatology

Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice

Gianluca Cipriani et al.

GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

Effects of naloxegol on whole gut transit in opioid-naive healthy subjects receiving codeine: A randomized, controlled trial

H. Halawi et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2018)

Article Multidisciplinary Sciences

Estrogen receptor beta controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage

F. D'Errico et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

Sebastiaan De Schepper et al.

Article Gastroenterology & Hepatology

Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum

M. Grover et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2017)

Article Multidisciplinary Sciences

Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis

Subhash Kulkarni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Immunology

Cholinergic Modulation of Type 2 immune Responses

Goele Bosmans et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Gastroenterology & Hepatology

Effects of NK1 receptors on gastric motor functions and satiation in healthy humans: results from a controlled trial with the NK1 antagonist aprepitant

Deepti Jacob et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2017)

Article Gastroenterology & Hepatology

Gastric Motor Dysfunction in Patients With Functional Gastroduodenal Symptoms

Seon-Young Park et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis

A. E. Bharucha et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2016)

Article Gastroenterology & Hepatology

Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers

A. D. Nelson et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2016)

Article Gastroenterology & Hepatology

Prokinetics in Gastroparesis

Andres Acosta et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2015)

Article Medicine, Research & Experimental

Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131

Lex Van der Ploeg et al.

LIFE SCIENCES (2014)

Article Gastroenterology & Hepatology

Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis

C. E. Bernard et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2014)

Review Gastroenterology & Hepatology

Clinical Guideline: Management of Gastroparesis

Michael Camilleri et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2013)

Article Gastroenterology & Hepatology

The Ghrelin Agonist RM-131 Accelerates Gastric Emptying of Solids and Reduces Symptoms in Patients With Type 1 Diabetes Mellitus

Andrea Shin et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2013)

Review Gastroenterology & Hepatology

Systematic review: cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders

J. Tack et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2012)

Article Gastroenterology & Hepatology

Effect of Mosapride Citrate on Gastric Emptying in Interferon-Induced Gastroparesis

Etsushi Kawamura et al.

DIGESTIVE DISEASES AND SCIENCES (2012)

Article Gastroenterology & Hepatology

Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants

M. Camilleri et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2012)

Article Gastroenterology & Hepatology

Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium

M. Grover et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2012)

Article Gastroenterology & Hepatology

Cellular Changes in Diabetic and Idiopathic Gastroparesis

Madhusudan Grover et al.

GASTROENTEROLOGY (2011)

Article Gastroenterology & Hepatology

Influence of tegaserod on proximal gastric tone and on the perception of gastric distention in functional dyspepsia

J. Tack et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2011)

Article Clinical Neurology

Advantages of Azithromycin Over Erythromycin in Improving the Gastric Emptying Half-Time in Adult Patients With Gastroparesis

Jean M Larson et al.

Journal of Neurogastroenterology and Motility (2010)

Article Gastroenterology & Hepatology

Factors Associated with Symptom Response to Pyloric Injection of Botulinum Toxin in a Large Series of Gastroparesis Patients

Radoslav Coleski et al.

DIGESTIVE DISEASES AND SCIENCES (2009)

Article Gastroenterology & Hepatology

Efficacy and tolerability of cinitapride in the treatment of functional dyspepsia and delayed gastric emptying

Piero Portincasa et al.

GASTROENTEROLOGIA Y HEPATOLOGIA (2009)

Review Gastroenterology & Hepatology

Actions and therapeutic pathways of ghrelin for gastrointestinal disorders

Michael Camilleri et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

Tegaserod treatment for dysmotility-like functional dyspepsia: Results of two randomized, controlled trials

Nimish Vakil et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)

Article Gastroenterology & Hepatology

Botulinum toxin a for the treatment of delayed gastric emptying

Frank K. Friedenberg et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)

Article Gastroenterology & Hepatology

A stable isotope breath test with a standard meal for abnormal gastric emptying of solids in the clinic and in research

Lawrence A. Szarka et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2008)

Article Gastroenterology & Hepatology

Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis

J. Arts et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2007)

Article Gastroenterology & Hepatology

Influence of ghrelin on interdigestive gastrointestinal motility in humans

J Tack et al.

Article Pharmacology & Pharmacy

Desensitization of the human motilin receptor by motilides

L Thielemans et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Review Gastroenterology & Hepatology

Review article:: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics

M Tonini et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2004)

Article Pharmacology & Pharmacy

The effect of sildenafil on gastric emptying in patients with end-stage renal failure and symptoms of gastroparesis

V Dishy et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2004)

Article Gastroenterology & Hepatology

Long-term cisapride treatment improves diabetic gastroparesis but not glycaemic control

B Braden et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2002)

Article Gastroenterology & Hepatology

Pharmacological modulation of human gastric volumes demonstrated noninvasively using SPECT imaging

SS Liau et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2001)

Article Medicine, Research & Experimental

Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy

CC Watkins et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)