Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.657033
Keywords
ferroptosis; lipid metabolism; iron metabolism; glutathione peroxidase 4; coenzyme Q(10); central nervous system diseases
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Funding
- Guangdong Basic and Applied Basic Research Foundation [2019A1515012138]
- Guangdong Provincial Key Laboratory Construction Foundation [2017B030314030]
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Ferroptosis is a novel form of programmed cell death involving iron metabolism and CNS diseases, which may offer new perspectives for the development of therapeutic agents.
Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q(10)-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson's disease, Alzheimer's disease, and Huntington's disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.
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