4.7 Article

Discovery of New Potent anti-MERS CoV Fusion Inhibitors

Related references

Note: Only part of the references are listed.
Review Cell Biology

Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms: A systematic review of in vitro and in vivo studies

Simin Seyedpour et al.

Summary: This study systematically evaluated recent in vitro and in vivo investigations targeting SARS-CoV-2 cell entry, finding that SARS-CoV-2 primarily enters host cells through the S protein utilizing ACE2 or CD147 as receptors. Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms mainly focus on targeting virus receptors on the host, neutralizing spike protein, interfering with virus fusion to host cells, and disrupting endosomal and non-endosomal dependent pathways.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Pathology

Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder

Stephanie F. Greene et al.

Summary: Afrezza, delivered through the Gen2 inhaler, demonstrated good pulmonary safety in long-term nonclinical studies, with controlled effects on rats and dogs and no carcinogenic potential. Exposure to Technosphere particles may cause nasal damage, but the impact on the lungs is minimal.

TOXICOLOGIC PATHOLOGY (2021)

Article Biochemistry & Molecular Biology

Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike 52 Subunit

Mahmoud Kandeel et al.

Summary: The study aimed to develop new fusion inhibitors against SARS-CoV-2, designing 12 peptides with peptide #2 demonstrating potent inhibition of SARS-CoV-2 S-mediated cell-cell fusion at 1 μM concentration. This shows promise in the development of new prophylactic and therapeutic agents against SARS-CoV-2.

BIOMOLECULES & THERAPEUTICS (2021)

Article Medicine, General & Internal

Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease

Aaron Waxman et al.

Summary: In patients with pulmonary hypertension due to interstitial lung disease, inhaled treprostinil significantly improved exercise capacity and clinical outcomes compared to placebo in a 16-week trial. Adverse events such as cough, headache, dyspnea, dizziness, nausea, fatigue, and diarrhea were commonly reported.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Infectious Diseases

The risk factors associated with MERS-CoV patient fatality: A global survey

Jamal Ahmadzadeh et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2020)

Article Biochemistry & Molecular Biology

Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers

Mahmoud Kandeel et al.

BIOMOLECULES & THERAPEUTICS (2020)

Article Biochemistry & Molecular Biology

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Waradon Sungnak et al.

NATURE MEDICINE (2020)

Review Biochemistry & Molecular Biology

Application of Fragment-Based Drug Discovery to Versatile Targets

Qingxin Li

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Review Microbiology

Antibody-Based Immunotherapeutic Strategies for COVID-19

Jamal Hussen et al.

PATHOGENS (2020)

Article Chemistry, Physical

General Purpose Water Model Can Improve Atomistic Simulations of Intrinsically Disordered Proteins

Parviz Seifpanahi Shabane et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2019)

Article Multidisciplinary Sciences

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

Shuai Xia et al.

SCIENCE ADVANCES (2019)

Article Chemistry, Medicinal

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

Anushka C. Galasiti Kankanamalage et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biotechnology & Applied Microbiology

Rigid amphipathic fusion inhibitors demonstrate antiviral activity against African swine fever virus

Astghik Hakobyan et al.

JOURNAL OF GENERAL VIROLOGY (2018)

Article Multidisciplinary Sciences

Potent peptidic fusion inhibitors of influenza virus

Rameshwar U. Kadam et al.

SCIENCE (2017)

Article Biochemistry & Molecular Biology

Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors

Vathan Kumar et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2016)

Review Pharmacology & Pharmacy

Peptide therapeutics: current status and future directions

Keld Fosgerau et al.

DRUG DISCOVERY TODAY (2015)

Article Chemistry, Medicinal

Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

Song Feng et al.

ACS MEDICINAL CHEMISTRY LETTERS (2015)

Article Multidisciplinary Sciences

Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

Sofie Stalmans et al.

PLOS ONE (2015)

Article Multidisciplinary Sciences

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

Lu Lu et al.

NATURE COMMUNICATIONS (2014)

Review Biotechnology & Applied Microbiology

Progress in the Identification of Dengue Virus Entry/Fusion Inhibitors

Carolina De La Guardia et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques

Darryl Falzarano et al.

NATURE MEDICINE (2013)

Article Biochemistry & Molecular Biology

BeAtMuSiC: prediction of changes in protein-protein binding affinity on mutations

Yves Dehouck et al.

NUCLEIC ACIDS RESEARCH (2013)

Review Biochemical Research Methods

From in silico target prediction to multi-target drug design: Current databases, methods and applications

Alexios Koutsoukas et al.

JOURNAL OF PROTEOMICS (2011)

Article Multidisciplinary Sciences

Target identification using drug affinity responsive target stability (DARTS)

Brett Lomenick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): In search of potent SARS-CoV entry inhibitors

Ling-Hon Matthew Chu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2008)

Article Chemistry, Multidisciplinary

A novel approach using functional peptides for efficient intestinal absorption of insulin

Mariko Morishita et al.

JOURNAL OF CONTROLLED RELEASE (2007)