Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.702445
Keywords
inorganic nanoparticles (iNPs); epidermal growth factor receptor (EGFR); molecular targeted; multifunctional nanotherapeutics; cancer treatment
Categories
Funding
- National Natural Science Foundation of China [21871246]
- Grant of Jilin Province Science and Technology Committee [20200201082JC]
- Science and Technology Innovation and Development projects of Jilin City [20190601178]
- Jilin Province Education Department the Science and Technology development project [JJKH20200741KJ, JJKH20200449KJ]
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Inorganic nanomaterials are increasingly utilized in EGFR-mediated therapy to address limitations and enhance the efficacy of molecular targeted cancer treatment. Their ease of preparation, modification, and biosecurity make them promising candidates for cancer treatment research aimed at improving EGFR-targeted therapy.
Epidermal growth factor receptor (EGFR) is an anticancer drug target for a number of cancers, such as non-small cell lung cancer. However, unsatisfying treatment effects, terrible side-effects, and development of drug resistance are current insurmountable challenges of EGFR targeting treatments for cancers. With the advancement of nanotechnology, an increasing number of inorganic nanomaterials are applied in EGFR-mediated therapy to improve those limitations and further potentiate the efficacy of molecular targeted cancer therapy. Given their facile preparation, easy modification, and biosecurity, inorganic nanoparticles (iNPs) have been extensively explored in cancer treatments to date. This review presents an overview of the application of some typical metal nanoparticles and nonmetallic nanoparticles in EGFR-targeted therapy, then discusses and summarizes the relevant advantages. Moreover, we also highlight future perspectives regarding their remaining issues. We hope these discussions inspire future research on EGFR-targeted iNPs.
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