Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.690612
Keywords
asiatic acid; tongue cancer; endoplasmic reticulum stress; GRP78; calpain; apoptosis
Categories
Funding
- Natural Science Foundation of Liaoning Province [20180550044]
- Basic Research Program [JYTJCZR201906]
- Liaoning Distinguished Professor Project [XLYC1802113]
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Asiatic acid (AA) is shown to induce apoptotic death in tongue cancer cells in vitro and in vivo, potentially through mechanisms involving increased calcium levels and endoplasmic reticulum stress. This suggests that AA could be a promising therapeutic tool for tongue cancer treatment.
Asiatic acid (AA) has been shown to induce apoptotic death in a range of cancers, but the mechanisms whereby it can inhibit tongue cancer growth have yet to be clarified. Herein, we explored the effects of AA on tongue cancer cells and found that it induced their apoptotic death in vitro and in vivo, while additionally impairing xenograft tumor growth in vivo. From a mechanistic perspective, AA treatment was associated with increases in levels of calcium and the calcium- dependent protease calpain, and it further induced endoplasmic reticulum (ER) stress and consequent Grp78-related IRE1 alpha and JNK phosphorylation, ultimately driving caspase-3 activation and apoptotic death. Together, these results highlight AA as a promising tool for the therapeutic treatment of tongue cancer in clinical practice.
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