Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.745061
Keywords
interleukin-6; inflammation; atherosclerosis; ischemic stroke; target; IL-6R alpha
Categories
Funding
- National Natural Science Foundation of China [31871169, 81600040]
- province Natural Science Foundation of Hu Nan [2020JJ8032, 2021 JJ 30601]
- Innovation guidance project of Hu Nan [2018SK51606, 2018SK51703]
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Cardio-Cerebrovascular Disease, a combination of cardiovascular disease and cerebrovascular disease, is a serious threat to human health. Studies have shown that inflammatory factors such as Interleukin-6 play a crucial role in vascular plaque stability, incidence of events, and diseases like atherosclerosis, myocardial infarction, etc. Targeting interleukin-6 may provide a potential strategy for the prevention and treatment of Cardio-Cerebrovascular Diseases.
Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incidence of cardio-cerebrovascular event, and involves in the process of Cardio-Cerebrovascular Diseases. Interleukin-6 is a widely used cytokine that causes inflammation and oxidative stress, which would further result in cardiac and cerebral injury. The increased expression of interleukin-6 is closely related to atherosclerosis, myocardial infarction, heart failure and ischemic stroke. It is a key risk factor for these diseases by triggering inflammatory reaction and inducing other molecules release. Therefore, interleukin-6 may become a potential target for Cardio-Cerebrovascular Diseases in the future. This paper is aimed to discuss the expression changes and pathological mechanisms of interleukin-6 in Cardio-Cerebrovascular Diseases, and to provide a novel strategy for the prevention and treatment of Cardio-Cerebrovascular Diseases.
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