Sleep Disturbances in Autoimmune Neurologic Diseases: Manifestation and Pathophysiology

Autoimmune neurologic diseases are a new category of immune-mediated disease demonstrating a widely varied spectrum of clinical manifestations. Recently, sleep disturbances in patients with autoimmune neurologic diseases have been reported to have an immense negative impact on the quality of life. Excessive daytime sleep, rapid eye movement sleep behavior disorder (RBD), and narcolepsy are the most frequent sleep disorders associated with autoimmune neurologic diseases. Sleep disturbances might be the initial symptoms of disease or persist throughout the course of the disease. In this review, we have discussed sleep disturbances in different autoimmune neurologic diseases and their potential pathophysiological mechanisms.

Automated summary

Autoimmune neurologic diseases are a new type of immune-mediated diseases with diverse clinical manifestations. Sleep disturbances, including excessive daytime sleep, RBD, and narcolepsy, have been reported to have a significant negative impact on the quality of life in patients with autoimmune neurologic diseases. These sleep disturbances can be either initial symptoms or persistent throughout the disease course, and they are believed to be associated with underlying pathophysiological mechanisms.