Related references
Note: Only part of the references are listed.Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel A Meta-analysis
Brian W. Kunkle et al.
JAMA NEUROLOGY (2021)
Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linked DNAJC6 mutations
Noviana Wulansari et al.
SCIENCE ADVANCES (2021)
STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease
Vladimir A. Vigont et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Treatment of a Mouse Model of ALS by In Vivo Base Editing
Colin K. W. Lim et al.
MOLECULAR THERAPY (2020)
Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome
Matthias Arnold et al.
NATURE COMMUNICATIONS (2020)
Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons
Tim Ahfeldt et al.
STEM CELL REPORTS (2020)
Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins
Masin Abo-Rady et al.
STEM CELL REPORTS (2020)
Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4
Michael E. Belloy et al.
JAMA NEUROLOGY (2020)
Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD
Ruxandra Dafinca et al.
STEM CELL REPORTS (2020)
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair
Nidaa A. Ababneh et al.
HUMAN MOLECULAR GENETICS (2020)
The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations
Vivian Chen et al.
HUMAN MOLECULAR GENETICS (2020)
Characterization of a pathogenic variant in GBA for Parkinson's disease with mild cognitive impairment patients
Zhiqiang Jiang et al.
MOLECULAR BRAIN (2020)
CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease
Kinga Szigeti et al.
EBIOMEDICINE (2020)
Using High-Content Screening to Generate Single-Cell Gene-Corrected Patient-Derived iPS Clones Reveals Excess Alpha-Synuclein with Familial Parkinson's Disease Point Mutation A30P
Peter Barbuti et al.
CELLS (2020)
Generation of gene-corrected iPSCs line (KETUi001-A) from a PARK8 patient iPSCs with familial Parkinson's disease carrying the I2020T mutation in LRRK2
Etsuro Ohta et al.
STEM CELL RESEARCH (2020)
Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral Sclerosis
Byung Woo Kim et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2020)
A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington's Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities
Tuyana Malankhanova et al.
JOURNAL OF PERSONALIZED MEDICINE (2020)
CRISPR-Cas9: A Promising Genome Editing Therapeutic Tool for Alzheimer's Disease-A Narrative Review
Nirmal Chandra Barman et al.
NEUROLOGY AND THERAPY (2020)
Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition
Samantha C. Burnham et al.
NEUROBIOLOGY OF AGING (2020)
The genome editing revolution: review
Ahmad M. Khalil
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2020)
Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects
Jolene Ooi et al.
CELL REPORTS (2019)
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD
Stephen Moore et al.
ACTA NEUROPATHOLOGICA (2019)
Silencing of the Mutant Huntingtin Gene through CRISPR-Cas9 Improves the Mitochondrial Biomarkers in an In Vitro Model of Huntington's Disease
Gary L. Dunbar et al.
CELL TRANSPLANTATION (2019)
In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway
Yuan Cai et al.
SCIENCE ADVANCES (2019)
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells
Christian B. Lessard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration
Sanne E. Klompe et al.
NATURE (2019)
Inserting DNA with CRISPR
Zhonggang Hou et al.
SCIENCE (2019)
RNA-guided DNA insertion with CRISPR-associated transposases
Jonathan Strecker et al.
SCIENCE (2019)
CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model
Freja K. Ekman et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2019)
TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models
Ying Guo et al.
FASEB JOURNAL (2019)
CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease
Marija Fjodorova et al.
STEM CELL REPORTS (2019)
LIN28A loss of function is associated with Parkinson's disease pathogenesis
Mi-Yoon Chang et al.
EMBO JOURNAL (2019)
Prediction of off-target specificity and cell-specific fitness of CRISPR-Cas System using attention boosted deep learning and network-based gene feature
Qiao Liu et al.
PLOS COMPUTATIONAL BIOLOGY (2019)
Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease
Tenielle Porter et al.
NEUROBIOLOGY OF AGING (2019)
A new era of gene editing for the treatment of human diseases
K. C. Mandip et al.
SWISS MEDICAL WEEKLY (2019)
Huntington's disease: a clinical review
P. McColgan et al.
EUROPEAN JOURNAL OF NEUROLOGY (2018)
Cytogenetic Analysis of the Results of Genome Editing on the Cell Model of Parkinson's Disease
A. S. Vetchinova et al.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2018)
Integrating DNA damage repair with the cell cycle
Johanne M. Murray et al.
CURRENT OPINION IN CELL BIOLOGY (2018)
Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism
Naoki Inoue et al.
EMBO REPORTS (2018)
Comprehensive analysis of the mutation spectrum in 301 German ALS families
Kathrin Mueller et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
Aude Nicolas et al.
NEURON (2018)
Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD
Boris Kantor et al.
MOLECULAR THERAPY (2018)
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage (vol 551, pg 464, 2017)
Nicole M. Gaudelli et al.
NATURE (2018)
Introducing an expanded CAG tract into the huntingtin gene causes a wide spectrum of ultrastructural defects in cultured human cells
Ksenia N. Morozova et al.
PLOS ONE (2018)
An updated review of Parkinson's disease genetics and clinicopathological correlations
M. Ferreira et al.
ACTA NEUROLOGICA SCANDINAVICA (2017)
CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo
Alex Mas Monteys et al.
MOLECULAR THERAPY (2017)
The control of DNA repair by the cell cycle
Nicole Hustedt et al.
NATURE CELL BIOLOGY (2017)
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Diana Chang et al.
NATURE GENETICS (2017)
Recruitment of CRISPR-Cas systems by Tn7-like transposons
Joseph E. Peters et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells
Xiaohong Xu et al.
STEM CELL REPORTS (2017)
FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling
Jonathan Arias-Fuenzalida et al.
STEM CELL REPORTS (2017)
In vivo genome editing improves motor function and extends survival in a mouse model of ALS
Thomas Gaj et al.
SCIENCE ADVANCES (2017)
Cell cycle-dependent control of homologous recombination
Xin Zhao et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2017)
Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
Steve Horvath et al.
AGING-US (2016)
Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9
Jun Wan Shin et al.
HUMAN MOLECULAR GENETICS (2016)
Origins of Programmable Nucleases for Genome Engineering
Srinivasan Chandrasegaran et al.
JOURNAL OF MOLECULAR BIOLOGY (2016)
Genome-editing Technologies for Gene and Cell Therapy
Morgan L. Maeder et al.
MOLECULAR THERAPY (2016)
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Alexis C. Komor et al.
NATURE (2016)
Genome-Editing Technologies: Principles and Applications
Thomas Gaj et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
Takeshi Maruyama et al.
NATURE BIOTECHNOLOGY (2015)
An Overview of the Molecular Mechanisms of Recombinational DNA Repair
Stephen C. Kowalczykowski
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
Genetic instability in budding and fission yeast-sources and mechanisms
Adrianna Skoneczna et al.
FEMS MICROBIOLOGY REVIEWS (2015)
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
Hiroshi Nishimasu et al.
CELL (2014)
Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair
Anuja Mehta et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Transcription activator-like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing
Ning Sun et al.
BIOTECHNOLOGY AND BIOENGINEERING (2013)
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Seung Woo Cho et al.
NATURE BIOTECHNOLOGY (2013)
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Jean-Charles Lambert et al.
NATURE GENETICS (2013)
Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells
Mahru C. An et al.
CELL STEM CELL (2012)
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
J. Ross Chapman et al.
MOLECULAR CELL (2012)
Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors
Dong Deng et al.
SCIENCE (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann et al.
ALZHEIMERS & DEMENTIA (2011)
Double-Strand Break End Resection and Repair Pathway Choice
Lorraine S. Symington et al.
ANNUAL REVIEW OF GENETICS, VOL 45 (2011)
Genome Engineering With Zinc-Finger Nucleases
Dana Carroll
GENETICS (2011)
A TALE nuclease architecture for efficient genome editing
Jeffrey C. Miller et al.
NATURE BIOTECHNOLOGY (2011)
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
Mariely DeJesus-Hernandez et al.
NEURON (2011)
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Alan E. Renton et al.
NEURON (2011)
Regulation of Homologous Recombination in Eukaryotes
Wolf-Dietrich Heyer et al.
ANNUAL REVIEW OF GENETICS, VOL 44 (2010)
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
Josiane E. Garneau et al.
NATURE (2010)
Genome editing with modularly assembled zinc-finger nucleases
Jin-Soo Kim et al.
NATURE METHODS (2010)
CRISPR/Cas, the Immune System of Bacteria and Archaea
Philippe Horvath et al.
SCIENCE (2010)
The DNA-damage response in human biology and disease
Stephen P. Jackson et al.
NATURE (2009)
Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
Jens Boch et al.
SCIENCE (2009)
A Simple Cipher Governs DNA Recognition by TAL Effectors
Matthew J. Moscou et al.
SCIENCE (2009)
Mechanism of eukaryotic homologous recombination
Joseph San Filippo et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2008)
Unexpected failure rates for modular assembly of engineered zinc fingers
Cherie L. Ramirez et al.
NATURE METHODS (2008)
CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou et al.
SCIENCE (2007)
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
C Allen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Engineering polydactyl zinc-finger transcription factors
RR Beerli et al.
NATURE BIOTECHNOLOGY (2002)
DNA double-strand breaks: signaling, repair and the cancer connection
KK Khanna et al.
NATURE GENETICS (2001)
Repair of endogenous DNA damage
T Lindahl et al.
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (2000)
Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
J Smith et al.
NUCLEIC ACIDS RESEARCH (2000)
Share Paper
