Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2021.720371
Keywords
Rac1; long term potentiation; PI3K; LIMK; PKC?/?; PKM zeta
Categories
Funding
- Project of the Foundation of National Natural Science of China [32030051, 31970956]
Ask authors/readers for more resources
Rac1 activation has opposite effects on the induction and maintenance of LTP in the hippocampus, modulating different signaling pathways during the different stages; activation of Rac1 during LTP induction leads to PKC ι/λ activation, while activation of Rac1 during LTP maintenance leads to PKM zeta inhibition.
Rac1 is a small GTPase of the Rho family. A previous study showed that the activation of Rac1 had an opposing effect on induction and maintenance of long-term potentiation (LTP) in the hippocampus. However, the molecular mechanism underlying this opposing effect remains to be addressed. In the present work, we find that the activation of Rac1 during the induction of LTP leads to an activation of PKC iota/lambda by phosphatidylinositol-3-kinase (PI3K), whereas the activation of Rac1 during the maintenance of LTP leads to the inhibition of PKM zeta by LIM_kinase (LIMK) in the hippocampus. This result suggests that during different stages of LTP, the activation of Rac1 can modulate different signaling pathways, which leads to an opposing effect on the induction and maintenance of LTP in the hippocampus.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available