4.5 Review

Spatiotemporal Regulation of Transcript Isoform Expression in the Hippocampus

Journal

FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 14, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2021.694234

Keywords

RNA localization; alternative splicing; subcellular localization; hippocampus; Cdc42; BDNF; alternative isoform expression; alternate UTR

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Funding

  1. National Institute of Mental Health [R00MH109626]

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Proper development and plasticity of hippocampal neurons require specific RNA isoforms to be expressed in the right place at the right time. This review describes the RNA processing strategies utilized by hippocampal neurons to regulate the spatiotemporal expression of critical genes. The hippocampus serves as an ideal investigative model for uncovering isoform-specific mechanisms that restrict transcript expression in space and time.
Proper development and plasticity of hippocampal neurons require specific RNA isoforms to be expressed in the right place at the right time. Precise spatiotemporal transcript regulation requires the incorporation of essential regulatory RNA sequences into expressed isoforms. In this review, we describe several RNA processing strategies utilized by hippocampal neurons to regulate the spatiotemporal expression of genes critical to development and plasticity. The works described here demonstrate how the hippocampus is an ideal investigative model for uncovering alternate isoform-specific mechanisms that restrict the expression of transcripts in space and time.

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