Update on the effects of GLP-1 receptor agonists for the treatment of polycystic ovary syndrome

Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) offer a unique opportunity to simultaneously address various comorbid associated conditions and phenotypic presentations of polycystic ovary syndrome (PCOS) as these agents improve insulin sensitivity, reduce cardiovascular disease (CVD) risk, result in weight loss, and improve nonalcoholic fatty liver disease. Areas covered: The authors describe trials conducted during the last 5 years and provide an update on exenatide and liraglutide use in PCOS women. Information from the studies investigating GLP-1 RAs effects on reducing CVD risk in PCOS is also presented. Expert opinion: Exenatide and liraglutide are good options for the treatment of PCOS when used alone or in combination with metformin. Especially strong consideration should be given to GLP-1 RAs when developing treatment strategies for PCOS women who are overweight or obese, glucose intolerant, have CVD or its attendant risk factors, and/or are seeking treatment for infertility.

Automated summary

GLP-1 receptor agonists provide a unique opportunity to address various comorbidities and phenotypic presentations of polycystic ovary syndrome, including improving insulin sensitivity, reducing CVD risk, inducing weight loss, and benefiting nonalcoholic fatty liver disease. Exenatide and liraglutide are effective options for PCOS treatment, especially in overweight or obese patients, those with diabetes, CVD or seeking infertility treatment.