Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives

Vitamin E is easily oxidized by light, air, oxidizing agents and heat, limiting its application in many ways. Compared to vitamin E, vitamin E ester derivatives exhibit improved stability and a stronger antioxidant capacity, and even gain new biological functions. In recent years, enzymatic synthesis of vitamin E ester derivatives has received increasing attention due to its environmental friendliness, high catalytic efficiency, and inherent selectivity. This paper reviews the related progress of lipase-mediated preparation of vitamin E ester derivatives. The function of different vitamin E ester derivatives, and the main factors influencing the enzymatic acylation process, including enzyme species, acyl donor and acceptor, reaction media and water activity, are summarized in this paper. Finally, the perspective of lipase-catalyzed synthesis of vitamin E ester derivatives is also discussed.

Automated summary

Vitamin E is easily oxidized, limiting its applications, but its ester derivatives show improved stability and antioxidant capacity with new biological functions. Enzymatic synthesis of these derivatives is gaining attention for its environmental friendliness, high catalytic efficiency, and selectivity. Recent studies focus on lipase-mediated preparation of vitamin E ester derivatives, highlighting factors influencing the enzymatic acylation process and discussing the potential of lipase-catalyzed synthesis.