4.6 Article

Malic enzyme 2 promotes the progression of hepatocellular carcinoma via increasing triglyceride production

Journal

CANCER MEDICINE
Volume 10, Issue 19, Pages 6795-6806

Publisher

WILEY
DOI: 10.1002/cam4.4209

Keywords

HCC; ME2; migration; triglyceride; tumorigenesis

Categories

Funding

  1. Natural Science Foundation of China [81860320, 81960328, 81760325, 81560297]
  2. Guizhou Province Science and Technology Projects
  3. Guizhou foundation [1150, 1129]
  4. Guizhou foundation LH [7516]
  5. Young Scientific Talents Growth Project of Guizhou Provincial Education Department [KY [2017]163]
  6. Doctoral Initiation Fund of the Affiliated Hospital of Guizhou Medical University
  7. Funding for Innovation and Entrepreneurship of high-level overseas students in Guizhou Province [2019 01]

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The study found that ME2 plays an oncogenic role in HCC by promoting cell growth and migration, as well as increasing triglyceride production. Inhibition of ME2 can slow down the progression of HCC.
The incidence and mortality of hepatocellular carcinoma (HCC) are gradually increasing during the past years. Recently, some studies have reported that malic enzyme (ME) plays an important role in cancer development, while the involvement of ME2 in HCC remains still undetermined. Here, we demonstrated that ME2 played an oncogenic role in HCC. ME2 was overexpressed in HCC tissues. TCGA database showed that the ME2 transcript level was inversely associated with the survival of HCC patients. Loss-of-function and gain-of-function assays showed that ME2 promoted HCC cell growth and migration. Furthermore, the xenografted tumorigenesis of MHCC97H cells was retarded by ME2 knockdown. ME2 silencing also suppressed the cell cycle process and induced apoptosis. Mechanistically, ME2 potentiated triglyceride synthesis, inhibition of which suppressed the proliferation and migration. We propose that ME2 promotes HCC progression by increasing triglyceride production.

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