Noncanonical Functions of C1s Complement Its Canonical Functions in Renal Cancer

Complement activation contributes to tumor progression in several cancer types. In this issue, Daugan and colleagues propose complement component C1s and C4d as new markers of prognosis in clear cell renal cell carcinoma. The mechanism of action of C1s involves both canonical and intracellular, noncanonical functions. The results provide new molecular targets to prevent tumor escape from immune surveillance, which leads to tumor progression.

Automated summary

Complement activation plays a role in tumor progression, and C1s and C4d are proposed as new prognostic markers for clear cell renal cell carcinoma. The mechanism of action of C1s involves canonical and intracellular functions, and the results offer new molecular targets to prevent tumor escape from immune surveillance, thus leading to tumor progression.