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Repertoire Remodeling through CD4+ T-cell Depletion

CANCER IMMUNOLOGY RESEARCH (2021)

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Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer

Hiroyasu Aoki et al.

Summary: Transient depletion of CD4(+) cells leads to replacement of T-cell clones in the blood, which is associated with the extent of CD4(+) T-cell depletion and an increase in CD8(+) T-cell count. This clonal replacement of the TCR repertoire is linked to the expansion of tumor-reactive T-cell clones and antitumor responses.

CANCER IMMUNOLOGY RESEARCH (2021)

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