4.5 Article

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Journal

BRAIN AND BEHAVIOR
Volume 11, Issue 10, Pages -

Publisher

WILEY
DOI: 10.1002/brb3.2340

Keywords

cancer risk; depression; health behaviors; meta-analysis; psycho-oncology

Funding

  1. Dutch Cancer Society [VU2017-8288]

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The study aims to explore the relationship between psychosocial factors and cancer risk, including the association between psychosocial factors and various types of cancer (breast, lung, prostate, colorectal, etc.), the interaction between psychosocial factors and various cancer risk factors, and the mediating role of health behaviors in the relationship between psychosocial factors and cancer incidence.
Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

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