Journal
STEM CELLS INTERNATIONAL
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/6647651
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Funding
- National Natural Science Foundation of China [82071142, 81801010]
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The study found that cyclic tension mediated by iStrain promotes the differentiation of BMSCs towards osteogenesis and fibrogenesis, leading to changes in the alignment direction of cells and the lengthening of cell processes and cell body.
Bone marrow mesenchymal stem cells (BMSCs) are intraosseous stem cells, and the effects of tensile strain on BMSC differentiation mediate several bone-related treatments. To study the response of BMSCs under tension, we designed and developed a small cellular tension instrument, iStrain. When iStrain applied tension on BMSCs, these cells exhibited convergence in the alignment direction and lengthening of the cell processes and cell body. Real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting demonstrated that iStrain-mediated cyclic tension promotes the differentiation of BMSCs toward osteogenesis and fibrogenesis. And the mRNA and protein expression of differentiation-related genes changes with the extension of tension time.
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