Journal
GENOMICS
Volume 107, Issue 1, Pages 1-8Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2015.11.003
Keywords
DNA; RNA; Sequencing; Sequencer; History
Funding
- Engineering and Physical Sciences Research Council [1079579] Funding Source: researchfish
- Rosetrees Trust [M470] Funding Source: researchfish
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Determining the order of nucleic acid residues in biological samples is an integral component of a wide variety of research applications. Over the last fifty years large numbers of researchers have applied themselves to the production of techniques and technologies to facilitate this feat, sequencing DNA and RNA molecules. This time-scale has witnessed tremendous changes, moving from sequencing short oligonucleotides to millions of bases, from struggling towards the deduction of the coding sequence of a single gene to rapid and widely available whole genome sequencing. This article traverses those years, iterating through the different generations of sequencing technology, highlighting some of the key discoveries, researchers, and sequences along the way. (C) 2015 The Authors. Published by Elsevier Inc.
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