4.5 Article

Phytochemical profiling of Azima tetracantha Lam. leaf methanol extract and elucidation of its potential as a chain-breaking antioxidant, anti-inflammatory and anti-proliferative agent

Related references

Note: Only part of the references are listed.
Article Biology

Metabolic profiling and biological activities of the aerial parts of Micromeria imbricata Forssk. growing in Saudi Arabia

Hanan M. Al-Yousef et al.

Summary: The study investigated the phytochemical constituents and pharmacological properties of Micromeria imbricata extract from Saudi Arabia for the first time, revealing potential antioxidant, cytotoxic, and anti-obesity characteristics in the extract and its fractions.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

Review Biochemistry & Molecular Biology

Caspase-3: A primary target for natural and synthetic compounds for cancer therapy

Poonam Yadav et al.

Summary: Caspase-3 plays a crucial role in cancer treatment, with many compounds reported to have potential anticancer effects through caspase-3-mediated apoptosis; plant isolates have also demonstrated cytotoxicity through caspase-3-mediated apoptosis. Procaspase-activating compound-1 is the first FDA-approved orphan drug, and its synthetic derivative has shown anticancer activity.

CHEMICAL BIOLOGY & DRUG DESIGN (2021)

Review Biochemistry & Molecular Biology

Regulation of Tissue Inflammation by 12-Lipoxygenases

Abhishek Kulkarni et al.

Summary: 12-LOX is a key lipid metabolizing enzyme that plays an important role in inflammatory diseases. Increased activity of 12-LOX can lead to tissue damage and enhanced migration of immune cells, while inhibition of this enzyme can protect against disease development and progression in animal models.

BIOMOLECULES (2021)

Review Biochemistry & Molecular Biology

Oxidative Stress in Cancer Cell Metabolism

Saniya Arfin et al.

Summary: ROS play a crucial role in regulating pro-tumorigenic and anti-tumorigenic signaling pathways in cancer cells, and manipulating ROS production and regulating antioxidant defense systems can control tumor progression.

ANTIOXIDANTS (2021)

Review Cell Biology

The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications

Nohora Cristina Ayola-Serrano et al.

Summary: COVID-19 infection induces cytokine release syndrome, potentially involving the activation of 5-lipoxygenase (5-LOX) and the release of leukotrienes (LTs), which may exacerbate the severity of the disease.

INFLAMMATION RESEARCH (2021)

Review Pharmacology & Pharmacy

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications - An updated evidence-based review

Mohamed Farag et al.

Summary: Salvadora persica L., also known as Arak or Peelu, has a long history as a traditional medicinal plant used in various fields. Phytochemical investigations have revealed diverse secondary metabolites in S. persica, showcasing a range of pharmacological activities. Recent research has even suggested a potential activity against COVID-19 protease.

SAUDI PHARMACEUTICAL JOURNAL (2021)

Article Chemistry, Multidisciplinary

Phytochemical, Cytotoxic, and Antimicrobial Evaluation of the Fruits of Miswak Plant, Salvadora persica L.

Mohammed Al Bratty et al.

JOURNAL OF CHEMISTRY (2020)

Article Plant Sciences

Variation in the polyphenol composition, antioxidant, and anticancer activity among different Amaranthus species

Nivedya Cheerakuzhy House et al.

SOUTH AFRICAN JOURNAL OF BOTANY (2020)

Review Pharmacology & Pharmacy

Toll-like Receptors as a Novel Therapeutic Target for Natural Products Against Chronic Diseases

Arunaksharan Narayanankutty

CURRENT DRUG TARGETS (2019)

Article Mathematical & Computational Biology

EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide

Nabarun Roy et al.

INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES (2018)

Review Food Science & Technology

Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans

Shama V. Joseph et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2016)

Article Integrative & Complementary Medicine

Antioxidant capacity of chewing stick miswak Salvadora persica

Saleh A. Mohamed et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Article Pharmacology & Pharmacy

Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models

Paulrayer Antonisamy et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2011)

Article Agriculture, Multidisciplinary

Profiling glucosinolates, flavonoids, alkaloids, and other secondary metabolites in tissues of Azima tetracantha L. (Salvadoraceae)

RN Bennett et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2004)