Journal
NEURAL PLASTICITY
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/8643129
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [32071003]
- Department of Science and Technology of Sichuan Province [2020ZYD006]
- 1.3.5 Project for Disciplines of Excellence of West China Hospital, Sichuan University [ZYJC21034]
Ask authors/readers for more resources
This review highlights the crucial role of K2P channels in the nervous system, including their involvement in regulating membrane potential, cellular excitability, and potassium homeostasis. Additionally, it discusses the potential relevance of glial K2P channels in neurological disorders.
Two-pore-domain potassium (K2P) channels are widespread in the nervous system and play a critical role in maintaining membrane potential in neurons and glia. They have been implicated in many stress-relevant neurological disorders, including pain, sleep disorder, epilepsy, ischemia, and depression. K2P channels give rise to leaky K+ currents, which stabilize cellular membrane potential and regulate cellular excitability. A range of natural and chemical effectors, including temperature, pressure, pH, phospholipids, and intracellular signaling molecules, substantially modulate the activity of K2P channels. In this review, we summarize the contribution of K2P channels to neuronal excitability and to potassium homeostasis in glia. We describe recently discovered functions of K2P channels in glia, such as astrocytic passive conductance and glutamate release, microglial surveillance, and myelin generation by oligodendrocytes. We also discuss the potential role of glial K2P channels in neurological disorders. In the end, we discuss current limitations in K2P channel researches and suggest directions for future studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available