Journal
GENOME BIOLOGY AND EVOLUTION
Volume 8, Issue 8, Pages 2613-2623Publisher
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evw182
Keywords
Chlamydia suis; tet(C)-containing cassette; tetracycline selective pressure; comparative genomics; genomic diversification
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Funding
- Public Health Service from the National Institute of Health [R01 AI098843]
- National Science Foundation (NSF) [2009-65109-05760]
- Swiss National Science Foundation (SNSF) [P2ZHP3_158590]
- Swiss National Science Foundation (SNF) [P2ZHP3_158590] Funding Source: Swiss National Science Foundation (SNF)
- MRC [MR/K010174/1] Funding Source: UKRI
- Medical Research Council [MR/K010174/1B, MR/K010174/1] Funding Source: researchfish
- National Institute for Health Research [HPRU-2012-10080] Funding Source: researchfish
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Species closely related to the human pathogen Chlamydia trachomatis (Ct) have recently been found to cause zoonotic infections, posing a public health threat especially in the case of tetracycline resistant Chlamydia suis (Cs) strains. These strains acquired a tet(C)-containing cassette via horizontal gene transfer (HGT). Genomes of 11 Cs strains from various tissues were sequenced to reconstruct evolutionary pathway(s) for tet(C) HGT. Cs had the highest recombination rate of Chlamydia species studied to date. Admixture occurred among Cs strains and with Chlamydia muridarum but not with Ct. Although in vitro tet(C) cassette exchange with Ct has been documented, in vivo evidence may require examining human samples from Ct and Cs co-infected sites. Molecular-clock dating indicated that ancestral clades of resistant Cs strains predated the 1947 discovery of tetracycline, which was subsequently used in animal feed. The cassette likely spread throughout Cs strains by homologous recombination after acquisition from an external source, and our analysis suggests Betaproteobacteria as the origin. Selective pressure from tetracycline may be responsible for recent bottlenecks in Cs populations. Since tetracycline is an important antibiotic for treating Ct, zoonotic infections at mutual sites of infection indicate the possibility for cassette transfer and major public health repercussions.
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