Journal
GENOME BIOLOGY AND EVOLUTION
Volume 8, Issue 6, Pages 2036-2043Publisher
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evw135
Keywords
whole genome mapping; optical map; ST-258; carbapenem; KPC
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Funding
- NCATS NIH HHS [KL2 TR001862, UL1 TR001863] Funding Source: Medline
- NIAID NIH HHS [R21 AI114508, R15 AI047115] Funding Source: Medline
- NIMHD NIH HHS [T37 MD001368] Funding Source: Medline
- NIMH NIH HHS [F32 MH083469] Funding Source: Medline
- Wellcome Trust [200782/Z/16/Z] Funding Source: Medline
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Klebsiella pneumoniae has become one of the most dangerous causative agents of hospital infections due to the acquisition of resistance to carbapenems, one of the last resort families of antibiotics. Resistance is usually mediated by carbapenemases coded for by different classes of genes. A prolonged outbreak of carbapenem-resistant K. pneumoniae infections has been recently described in northeastern Ohio. Most strains isolated from patients during this outbreak belong to MLST sequence type 258 ( ST258). To understand more about this outbreak two isolates ( strains 140 and 677), one of them responsible for a fatal infection, were selected for genome comparison analyses. Whole genome map and sequence comparisons demonstrated that both strains are highly related showing 99% average nucleotide identity. However, the genomes differ at the so-called high heterogeneity zone ( HHZ) and other minor regions. This study identifies the potential value of the HHZ as a potential marker for K. pneumoniae clinical and epidemiological studies.
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