Journal
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Volume 10, Issue 16, Pages -Publisher
WILEY
DOI: 10.1161/JAHA.120.020302
Keywords
biomarker; placental growth factor; preeclampsia; pregnancy
Categories
Funding
- National Health and Medical Research Council [1065854, 1183854, 116071]
- Norman Beischer Medical Research Foundation
- Australian Government Research Training Program Scholarship
- RANZCOG Taylor Hammond Scholarship
- National Health and Medical Research Council Fellowships [1159261, 1146128, 1136418]
- National Health and Medical Research Council of Australia [1183854] Funding Source: NHMRC
Ask authors/readers for more resources
The study found that plasma GDF-15 levels were significantly increased in women more likely to develop preeclampsia or diagnosed with the condition. This suggests that GDF-15 may serve as a clinical biomarker and improve the sensitivity of the sFlt-1/PlGF ratio.
Background We investigated the biomarker potential of growth differentiation factor 15 (GDF-15), a stress response protein highly expressed in placenta, to predict preeclampsia. Methods and Results In 2 prospective cohorts (cohort 1: 960 controls, 39 women who developed preeclampsia; cohort 2: 950 controls, 41 developed preeclampsia), plasma concentrations of GDF-15 at 36 weeks' gestation were significantly increased among those who developed preeclampsia (P<0.001), area under the receiver operating characteristic curves (AUC) of 0.66 and 0.71, respectively. In cohort 2 a ratio of sFlt-1/PlGF (a clinical biomarker for preeclampsia) had a sensitivity of 61.0% at 83.2% specificity to predict those who will develop preeclampsia (AUC of 0.79). A ratio of GDF-15xsFlt-1/PlGF yielded a sensitivity of 68.3% at 83.2% specificity (AUC of 0.82). GDF-15 was consistently elevated across a number of international cohorts: levels were higher in placenta and blood from women delivering <34 weeks' gestation due to preterm preeclampsia in Melbourne, Australia; and in the blood at 26 to 32 weeks' gestation among 57 women attending the Manchester Antenatal Vascular Service (MAViS, UK) who developed preeclampsia (P=0.0002), compared with 176 controls. In the Preeclampsia Obstetric adVerse Events biobank (PROVE, South Africa), plasma GDF-15 was significantly increased in women with preeclampsia with severe features (P=0.02; n=14) compared to controls (n=14). Conclusions We conclude circulating GDF-15 is elevated among women more likely to develop preeclampsia or diagnosed with the condition. It may have value as a clinical biomarker, including the potential to improve the sensitivity of sFlt-1/PlGF ratio.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available