4.6 Article

Lung Respiratory Motion Estimation Based on Fast Kalman Filtering and 4D CT Image Registration

Journal

IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
Volume 25, Issue 6, Pages 2007-2017

Publisher

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JBHI.2020.3030071

Keywords

Computed tomography; Motion estimation; Image registration; Lung; Strain; Kalman filters; Estimation; Respiratory motion estimation; 4D CT; Image registration; Kalman filtering

Funding

  1. Fundamental Research Funds for the Central Universities (China)
  2. National Natural Science Foundation of China [81671848, 81371635]
  3. Key Research and Development Project of Shandong Province [2019GGX101022]

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This study proposes a method of lung respiratory motion estimation based on fast Kalman filtering and 4D CT image registration, which can accurately and quickly estimate physiological respiratory motion. By combining two GPU-accelerated image registration methods and adopting a multi-level processing strategy, the method successfully predicts respiratory motion states.
Respiratory motion estimation is an important part in image-guided radiation therapy and clinical diagnosis. However, most of the respiratory motion estimation methods rely on indirect measurements of external breathing indicators, which will not only introduce great estimation errors, but also bring invasive injury for patients. In this paper, we propose a method of lung respiratory motion estimation based on fast Kalman filtering and 4D CT image registration (LRME-4DCT). In order to perform dynamic motion estimation for continuous phases, a motion estimation model is constructed by combining two kinds of GPU-accelerated 4D CT image registration methods with fast Kalman filtering method. To address the high computational requirements of 4D CT image sequences, a multi-level processing strategy is adopted in the 4D CT image registration methods, and respiratory motion states are predicted from three independent directions. In the DIR-lab dataset and POPI dataset with 4D CT images, the average target registration error (TRE) of the LRME-4DCT method can reach 0.91 mm and 0.85 mm respectively. Compared with traditional estimation methods based on pair-wise image registration, the proposed LRME-4DCT method can estimate the physiological respiratory motion more accurately and quickly. Our proposed LRME-4DCT method fully meets the practical clinical requirements for rapid dynamic estimation of lung respiratory motion.

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