Journal
FRONTIERS IN PLANT SCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2021.682387
Keywords
plant protection; pesticide; dsRNA; SIGS; pesticide regulation
Categories
Funding
- COST (European Cooperation in Science and Technology)
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With increasing pest and pathogen challenges, there is a need for innovative and sustainable solutions for plant protection, such as RNA interference-based pesticides. These products target organisms specifically through the interaction of siRNAs with target RNAs. The regulatory frameworks for pesticide authorization in the US and EU are evolving to address the use of dsRNA-based pesticides.
Increasing pest and pathogen challenges as well as having fewer conventional pesticides to employ require innovative and sustainable solutions for plant protection. One group of pesticides that is in the pipeline and is expected to be subject to regulation and risk assessment procedures in the near future, is based on the natural gene silencing mechanism RNA interference (RNAi). These dsRNA-based products can be highly specific for a target organism due to the sequence-specific interaction between effective small interfering RNAs (siRNAs) and a complementary target RNA. General regulatory frameworks for pesticide authorization in the U.S. and in the EU are presented. In addition, production and application procedures and specific characteristics of dsRNA-based pesticides relevant for risk assessment and regulation are considered.
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