Journal
FRONTIERS IN MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.643422
Keywords
vaginal microbiota transplantation; bacterial vaginitis; antibiotics; Lactobacillus; gynecological diseases
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Funding
- National Natural Science Foundation of China [82060638]
- Academic and technical leaders of major disciplines in Jiangxi Province [20194BCJ22032]
- Double thousand plan of Jiangxi Province (high end Talents Project of scientific and technological innovation)
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Vaginal microbiota dysbiosis plays a significant role in gynecological infectious and non-infectious diseases, and intervention on microbiota composition is crucial for the treatment of gynecological diseases.
Vaginal microbiota dysbiosis, characterized by the loss of Lactobacillus dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antibiotics and/or probiotics are the mainstay of treatment, which show favorable therapeutic effects but also bring problems such as drug resistance and high recurrence. In this review, we discuss the role of vaginal microbiota dysbiosis in various gynecological infectious and non-infectious diseases, as well as the current and potential interventions.
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