Journal
GENETICS IN MEDICINE
Volume 19, Issue 4, Pages 448-456Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gim.2016.130
Keywords
BRCA1; BRCA2; genetic counseling; psychological adjustment; rapid testing
Categories
Funding
- Priority-Driven Collaborative Research Grant - Cancer Australia
- Cancer Council Australia
- National Breast Cancer Foundation [630405]
- Career Development Fellowship Award Level 2 [1003921]
- Senior Research Fellowship Level B from the National Health and Medical Research Council Australia [1078523]
- Early Career Fellowship from the National Breast Cancer Foundation [ECF-15-005]
- Psycho-oncology Cooperative Research Group (PoCoG)
- National Breast Cancer Foundation [ECF-15-005] Funding Source: researchfish
Ask authors/readers for more resources
Purpose: Increasingly, women newly diagnosed with breast cancer are being offered treatment-focused genetic testing (TFGT). As the demand for TFGT increases, streamlined methods of genetic education are needed. Methods: In this noninferiority trial, women aged <50 years with either a strong family history (FH+) or other features suggestive of a germ-line mutation (FH) were randomized before definitive breast cancer surgery to receive TFGT education either as brief written materials (intervention group (IG)) or during a genetic counseling session at a familial cancer clinic (usual-care group (UCG)). Women completed self-report questionnaires at four time points over 12 months. Results: A total of 135 women were included in the analysis, all of whom opted for TFGT. Decisional conflict about TFGT choice (primary outcome) was not inferior in the IG compared with the UCG (noninferiority margin of -10; mean difference = 2.45; 95% confidence interval -2.87-7.76; P = 0.36). Costs per woman counseled in the IG were significantly lower (AUD$89) compared with the UCG (AUD$173; t(115) = 6.02; P < 0.001). Conclusion: A streamlined model of educating women newly diagnosed with breast cancer about TFGT seems to be a cost-effective way of delivering education while ensuring that women feel informed and supported in their decision making, thus freeing resources for other women to access TFGT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available