Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs

Fibrosis is a complex and difficult to elucidate pathological process with no available therapies. Growing evidence implicates intestinal microbiota in the occurrence and development of fibrosis, and the potential mechanisms involved in different organs have been explored in several studies. In this review, we summarize the causative and preventive effects of gut microbiota on intestinal fibrosis, as well as the relationships between gut microbiota and fibrosis in other organs. Interestingly, several colonized microbes are associated with fibrosis via their structural components and metabolic products. They may also play essential roles in regulating inflammation and fibroblast activation or differentiation, which modulates extracellular matrix formation. While the relationships between intestinal fibrosis and gut microbiota remain unclear, lessons can be drawn from the effects of gut microbiota on hepatic, cardiac, nephritic, and pulmonary fibrosis. Various intestinal microbes alterations have been detected in different fibrotic organs; however, the results were heterogeneous. Mechanisms by which the intestinal microbiota regulate fibrotic processes in other organs, such as novel metabolic products or specific microbes, are also discussed. The specific microbiota associated with fibrosis in other organs could instruct future studies aiming to discover prospective mechanisms regulating intestinal fibrosis.

Automated summary

The intestinal microbiota plays a crucial role in the causative and preventive effects of intestinal fibrosis, as well as in the relationships with fibrosis in other organs. Colonized microbes are associated with fibrosis through their structural components and metabolic products, potentially regulating inflammation, fibroblast activation, and extracellular matrix formation in different organs. The findings suggest that understanding the mechanisms by which intestinal microbiota regulate fibrotic processes in other organs could provide insights for studying prospective mechanisms in intestinal fibrosis.