Journal
FRONTIERS IN MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.699913
Keywords
Yersinia pseudotuberculosis; Fur; aerobactin; siderophore; iron acquisition; oxidative stress; biofilm formation; virulence
Categories
Funding
- National Key Ramp
- D Program of China [2018YFA0901200]
- National Natural Science Foundation of China [31725003, 31670053, 31671292]
- China Postdoctoral Science Foundation [2020M673501]
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In the food-borne enteric pathogen Yersinia pseudotuberculosis, the aerobactin plays a critical role in iron acquisition and is directly repressed by the ferric uptake regulator in an iron concentration-dependent manner. It contributes to bacterial growth under iron-limited conditions and also plays important roles in biofilm formation, resistance to oxidative stress, ROS removal, and virulence of Y. pseudotuberculosis.
Aerobactin is a citrate-hydroxamate siderophore that is critical for the virulence of pathogenic enteric bacteria. However, although the aerobactin-producing iucABCD-iutA operon is distributed widely in the genomes of Yersinia species, none of the pathogenic Yersinia spp. was found to produce aerobactin. Here, we showed that the iucABCD-iutA operon in the food-borne enteric pathogen Yersinia pseudotuberculosis YPIII is a functional siderophore system involved in iron acquisition. The expression of the operon was found to be directly repressed by the ferric uptake regulator (Fur) in an iron concentration-dependent manner. In addition, we demonstrated that the aerobactin-mediated iron acquisition contributes to bacterial growth under iron-limited conditions. Moreover, we provided evidence that aerobactin plays important roles in biofilm formation, resistance to oxidative stress, ROS removal, and virulence of Y. pseudotuberculosis. Overall, our study not only uncovered a novel strategy of iron acquisition in Y. pseudotuberculosis but also highlighted the importance of aerobactin in the pathogenesis of Y. pseudotuberculosis.
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