4.6 Review

Major Insights in Dynamics of Host Response to SARS-CoV-2: Impacts and Challenges

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Blood biochemical parameters for assessment of COVID-19 in diabetic and non-diabetic subjects: a cross-sectional study

Syeda Umme Fahmida Malik et al.

Summary: This study identified blood biomarkers associated with the progression and severity of COVID-19 in type 2 diabetic (DM) and non-DM (NDM) patients. Ferritin and HbA1c levels were found to be especially important for DM patients, while CRP and Troponin-I could predict poor prognosis of COVID-19.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2022)

Article Immunology

Community-acquired Coinfection in Coronavirus Disease 2019: A Retrospective Observational Experience

Christopher J. Lehmann et al.

Summary: This report highlights the prevalence of coinfection among COVID-19 patients, especially those requiring admission to intensive care. Despite the low rate of coinfection, a high percentage of patients still received antibiotic treatment.

CLINICAL INFECTIOUS DISEASES (2021)

Letter Pharmacology & Pharmacy

Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID-19

Ricardo Pena-Silva et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Letter Virology

Pneumococcal coinfection in COVID-19 patients

Jessica M. Toombs et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

Review Virology

Proportion of asymptomatic coronavirus disease 2019: A systematic review and meta-analysis

Jingjing He et al.

Summary: Approximately 15.6% of confirmed COVID-19 patients are asymptomatic. Nearly half of the patients with no symptoms at detection time will develop symptoms later. Children are likely to have a higher proportion of asymptomatic infection than adults. Asymptomatic COVID-19 patients could have abnormal laboratory and radiational manifestations, which can be used as screening strategies to identify asymptomatic infection.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Virology

被撤回的出版物: Efficacy of favipiravir in COVID-19 treatment: a multi-center randomized study (Retracted article. See vol. 167, pg. 277, 2022)

Hany M. Dabbous et al.

Summary: Favipiravir shows promising efficacy in the treatment of COVID-19, reducing hospital stay and the need for mechanical ventilation.

ARCHIVES OF VIROLOGY (2021)

Review Infectious Diseases

Role of favipiravir in the treatment of COVID-19

Shashank Joshi et al.

Summary: Favipiravir has shown promising results in clinical studies worldwide, demonstrating potential efficacy against COVID-19, and is being included in treatment protocols by multiple countries.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Letter Infectious Diseases

Clinical efficacy and safety of favipiravir in the treatment of COVID-19 patients

Ping-Jen Chen et al.

JOURNAL OF INFECTION (2021)

Article Medicine, General & Internal

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

A. C. Kalil et al.

Summary: Combination treatment with baricitinib plus remdesivir was superior to remdesivir alone in reducing recovery time and accelerating improvement in clinical status among patients with Covid-19, notably among those receiving high-flow oxygen or noninvasive ventilation. The combination was associated with fewer serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Infectious Diseases

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness

Sabeena Ahmed et al.

Summary: Ivermectin, an FDA-approved anti-parasitic agent, was found to inhibit SARS-CoV-2 replication in vitro. A trial in Bangladesh showed that a 5-day course of ivermectin can promote viral clearance in adult patients with mild COVID-19.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: A randomized, comparative, open-label, multicenter, phase 3 clinical trial

Zarir F. Udwadia et al.

Summary: The study aimed to assess the efficacy and safety of favipiravir in adults with mild-to-moderate COVID-19. Results showed a significant improvement in time to clinical cure with favipiravir, although there was no statistically significant difference in viral shedding cessation time.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Article Medicine, General & Internal

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19 A Randomized Clinical Trial

Eduardo Lopez-Medina et al.

Summary: The study found that a 5-day course of ivermectin did not significantly improve the time to resolution of symptoms in adults with mild COVID-19, and does not support its use for treatment of mild COVID-19. Larger trials may be needed to understand the effects of ivermectin on other clinically relevant outcomes.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, General & Internal

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Merryn Voysey et al.

Summary: The AZD1222 vaccine has been approved for emergency use in the UK with an interval of 4-12 weeks between doses. Analysis shows that the vaccine is efficacious with two doses and provides immunoprotection after the first dose before the second dose is administered.

LANCET (2021)

Article Multidisciplinary Sciences

Detection of a SARS-CoV-2 variant of concern in South Africa

Houriiyah Tegally et al.

Summary: The article describes a newly emerged lineage of SARS-CoV-2, 501Y.V2, characterized by eight mutations in the spike protein, which may result in increased transmissibility or immune escape. This lineage originated in South Africa and quickly became dominant in Eastern Cape, Western Cape, and KwaZuluNatal provinces within weeks.

NATURE (2021)

Article Medicine, General & Internal

Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

I. O. Rosas et al.

Summary: In this randomized trial involving hospitalized patients with severe Covid-19 pneumonia, the use of tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease

Anam Liaqat et al.

Summary: COVID-19 pandemic may lead to myocardial damage, a major cause of death among patients. A study conducted in Pakistan found that around half of COVID-19 patients experienced myocardial injury, with elevated cardiac markers and abnormal ECG or echocardiography. Critical patients were more prone to cardiac damage.

SCIENTIFIC REPORTS (2021)

Article Critical Care Medicine

Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Francois-Xavier Lescure et al.

Summary: This study aimed to evaluate the safety and efficacy of sarilumab in patients with severe or critical COVID-19, but found no significant efficacy in patients admitted to the hospital receiving supplemental oxygen. Future adequately powered trials of targeted immunomodulatory therapies with survival as a primary endpoint are suggested for patients with critical COVID-19.

LANCET RESPIRATORY MEDICINE (2021)

Article Endocrinology & Metabolism

Immunological Characteristics in Type 2 Diabetes Mellitus Among COVID-19 Patients

Meifang Han et al.

Summary: The study found that COVID-19 patients with type 2 diabetes mellitus (T2DM) were more likely to have lymphopenia, hyperglycemia, and higher levels of certain laboratory parameters. The mortality rate was significantly elevated in diabetic cases, along with higher levels of inflammatory cytokines.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Infectious Diseases

Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients

Nurullah Okumus et al.

Summary: This study aimed to investigate the presence of gene mutations affecting ivermectin metabolism in patients with severe COVID-19 pneumonia, and evaluate the effectiveness and safety of ivermectin treatment. Clinical improvement rate was higher in the ivermectin group compared to the control group after 5 days of treatment. Ivermectin showed potential in increasing clinical recovery and improving prognostic laboratory parameters in severe COVID-19 patients, suggesting it could be considered as an alternative treatment option.

BMC INFECTIOUS DISEASES (2021)

Article Multidisciplinary Sciences

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Alexey Stukalov et al.

Summary: The study reports a concurrent multi-omics analysis of SARS-CoV-2 and SARS-CoV, revealing both distinct and common molecular mechanisms between these closely related coronaviruses, as well as their impact on the host cell proteome. The results of this study may provide insights into the design of virus- and host-directed therapies for these coronaviruses.

NATURE (2021)

Article Multidisciplinary Sciences

Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Erik Volz et al.

Summary: Genetic and testing data from England indicate that the SARS-CoV-2 variant B.1.1.7 has a transmission advantage over other lineages, showing a rapid expansion during autumn 2020. Analysis of S gene target failures (SGTF) in community-based diagnostic PCR testing suggests that B.1.1.7 is more transmissible than non-variant of concern lineages and has a significant transmission advantage, with a reproduction number 50% to 100% higher. Additionally, cases of B.1.1.7 appear to include a larger share of under 20-year-olds compared to non-variant cases.

NATURE (2021)

Review Genetics & Heredity

Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases

Abul Kalam Azad et al.

Summary: AQPs are integral membrane proteins involved in transmembrane diffusion of water and small solutes bidirectionally. They are functionally diverse and associated with a wide range of non-infectious diseases, while their role in infectious diseases remains to be fully evaluated. Studies suggest that AQPs can be regulated by microbial and parasitic infections, indicating their involvement in microbial pathogenesis, inflammation-related responses, and cell water homeostasis.

FRONTIERS IN GENETICS (2021)

Review Immunology

Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2

Ian McDonald et al.

Summary: This study provides a comparative evaluation of different vaccine platforms in terms of immunogenicity and efficacy. Vaccines generally result in mild and self-limiting adverse events. Different vaccines show varying levels of immunogenicity and efficacy.

NPJ VACCINES (2021)

Review Immunology

Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Ali Pormohammad et al.

Summary: This study systematically reviewed the clinical features of COVID-19 vaccines in clinical trials, finding that mRNA-based and adenovirus-vectored vaccines exhibited different efficacy and side effect profiles. Both types of vaccines showed high efficacy after the first and second doses, with mRNA-based vaccines having higher reported side effects.

VACCINES (2021)

Article Medicine, General & Internal

Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults A Randomized Clinical Trial

Nawal Al Kaabi et al.

Summary: This interim analysis of an ongoing randomized trial in the UAE and Bahrain evaluated the efficacy of two inactivated COVID-19 vaccines in preventing symptomatic cases and adverse events in healthy adults. The study found that both vaccines significantly reduced the risk of symptomatic COVID-19 compared to the control group, with efficacy rates of 72.8% and 78.1%. Serious adverse events were rare across all groups.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, General & Internal

Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Mine Durusu Tanriover et al.

Summary: The study presented the interim efficacy and safety results of the CoronaVac vaccine in a phase 3 clinical trial in Turkey, demonstrating high efficacy against PCR-confirmed symptomatic COVID-19 with good safety and tolerability profile. Results showed significant differences in the frequency of any adverse events between the vaccine and placebo groups, indicating excellent protective effects of the vaccine.

LANCET (2021)

Article Multidisciplinary Sciences

COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants

Pinja Jalkanen et al.

Summary: The study shows that the second dose of the BNT162b2 vaccine can induce cross-neutralization to some extent of SARS-CoV-2 variants, providing partial protection. Despite the reduced neutralization effect on the B.1.351 variant, the majority of vaccinees still have some level of protection.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Structure analysis of the receptor binding of 2019-nCoV

Yun Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Editorial Material Microbiology

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

Aiping Wu et al.

CELL HOST & MICROBE (2020)

Editorial Material Immunology

A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome

Shibo Jiang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Editorial Material Gastroenterology & Hepatology

Evidence for Gastrointestinal Infection of SARS-CoV-2

Fei Xiao et al.

GASTROENTEROLOGY (2020)

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Virology

Coronavirus infections and immune responses

Geng Li et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Review Medicine, General & Internal

The outbreak of COVID-19: An overview

Yi-Chi Wu et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2020)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Editorial Material Cardiac & Cardiovascular Systems

COVID-19 and the cardiovascular system

Ying-Ying Zheng et al.

NATURE REVIEWS CARDIOLOGY (2020)

Review Urology & Nephrology

The global epidemiology of hypertension

Katherine T. Mills et al.

NATURE REVIEWS NEPHROLOGY (2020)

Article Medicine, General & Internal

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia

Qun Li et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Sexual-dimorphism in human immune system aging

Eladio J. Marquez et al.

NATURE COMMUNICATIONS (2020)

Editorial Material Biochemistry & Molecular Biology

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms

Abdul Mannan Baig et al.

ACS CHEMICAL NEUROSCIENCE (2020)

Letter Cardiac & Cardiovascular Systems

Cardiovascular comorbidities, cardiac injury, and prognosis of COVID-19 in New York City

Toshiki Kuno et al.

AMERICAN HEART JOURNAL (2020)

Editorial Material Hematology

COVID-19 and mycoplasma pneumoniae coinfection

Bingwen Eugene Fan et al.

AMERICAN JOURNAL OF HEMATOLOGY (2020)

Editorial Material Peripheral Vascular Disease

Hypertension and COVID-19

Ernesto L. Schiffrin et al.

AMERICAN JOURNAL OF HYPERTENSION (2020)

Article Endocrinology & Metabolism

COVID-19 pandemic, coronaviruses, and diabetes mellitus

Ranganath Muniyappa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

Article Public, Environmental & Occupational Health

Case Report: The Importance of Novel Coronavirus Disease (COVID-19) and Coinfection with Other Respiratory Pathogens in the Current Pandemic

Karam Khaddour et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2020)

Letter Hematology

COVID-19 and ABO blood group: another viewpoint

Christiane Gerard et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

Article Biochemistry & Molecular Biology

The Architecture of SARS-CoV-2 Transcriptome

Dongwan Kim et al.

Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

Letter Medical Laboratory Technology

Coinfection of SARS-CoV-2 and multiple respiratory pathogens in children

Shupeng Jiang et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

Review Medical Laboratory Technology

COVID-19: progression of disease and intravascular coagulation - present status and future perspectives

Job Harenberg et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

Correction Biochemistry & Molecular Biology

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak (vol 30, 1346.e1, 2020)

Tao Zhang et al.

CURRENT BIOLOGY (2020)

Review Biochemistry & Molecular Biology

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

Shivraj Hariram Nile et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Review Biochemistry & Molecular Biology

IL-6: Relevance for immunopathology of SARS-CoV-2

E. O. Gubernatorova et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Editorial Material Endocrinology & Metabolism

Management of diabetes today: An exciting confusion

Antonio Ceriello

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

Editorial Material Medicine, Research & Experimental

Is BCG vaccination causally related to reduced COVID-19 mortality?

Masayuki Miyasaka

EMBO MOLECULAR MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy

Riccardo M. Inciardi et al.

EUROPEAN HEART JOURNAL (2020)

Article Clinical Neurology

COVID-19 and herpes zoster co-infection presenting with trigeminal neuropathy

A. C. A. de F. Ferreira et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

Article Gastroenterology & Hepatology

Effect of Gastrointestinal Symptoms in Patients With COVID-19

Zili Zhou et al.

GASTROENTEROLOGY (2020)

Letter Gastroenterology & Hepatology

COVID-19 in gastroenterology: a clinical perspective

John Ong et al.

Article Peripheral Vascular Disease

COVID-19 patients with hypertension have more severe disease: a multicenter retrospective observational study

Songjiang Huang et al.

HYPERTENSION RESEARCH (2020)

Editorial Material Immunology

COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

Toshio Hirano et al.

IMMUNITY (2020)

Article Infectious Diseases

Janus kinase inhibitor baricitinib is not an ideal option for management of COVID-19

D. Praveen et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Review Infectious Diseases

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

Jing Yang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Article Infectious Diseases

Transmission potential and severity of COVID-19 in South Korea

Eunha Shim et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Letter Medicine, General & Internal

Rates of Co-infection Between SARS-CoV-2 and Other Respiratory Pathogens

David Kim et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Letter Medicine, General & Internal

Seasonal Influenza Activity During the SARS-CoV-2 Outbreak in Japan

Haruka Sakamoto et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Medicine, General & Internal

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Safiya Richardson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Medicine, General & Internal

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Giacomo Grasselli et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Allergy

A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

Isabella Quinti et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Immunology

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

Guoping Li et al.

JOURNAL OF AUTOIMMUNITY (2020)

Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Demographic science aids in understanding the spread and fatality rates of COVID-19

Jennifer Beam Dowd et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Effective treatment of severe COVID-19 patients with tocilizumab

Xiaoling Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Phylogenetic network analysis of SARS-CoV-2 genomes

Peter Forster et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Letter Infectious Diseases

Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact

Fabrizio Cantini et al.

JOURNAL OF INFECTION (2020)

Letter Infectious Diseases

Regional air pollution persistence links to COVID-19 infection zoning

Antonio Frontera et al.

JOURNAL OF INFECTION (2020)

Article Virology

Tocilizumab treatment in COVID-19: A single center experience

Pan Luo et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Letter Virology

COVID-19 pneumonia treated with Sarilumab: A clinical series of eight patients

Maurizio Benucci et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Review Immunology

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

Christian A. Devaux et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)

Editorial Material Clinical Neurology

Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Ischemic Stroke

Eduard Valdes Valderrama et al.

STROKE (2020)

Review Biochemistry & Molecular Biology

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

Jiumeng Sun et al.

TRENDS IN MOLECULAR MEDICINE (2020)

Letter Public, Environmental & Occupational Health

A severe case with co-infection of SARS-CoV-2 and common respiratory pathogens

Xueting Ou et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

Review Cardiac & Cardiovascular Systems

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic

Elissa Driggin et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Medicine, General & Internal

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

Tao Chen et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Editorial Material Urology & Nephrology

Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology

Daniel Batlle et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Editorial Material Urology & Nephrology

The Novel Coronavirus 2019 epidemic and kidneys

Saraladevi Naicker et al.

KIDNEY INTERNATIONAL (2020)

Letter Infectious Diseases

Baricitinib for COVID-19: a suitable treatment? Reply

Peter J. Richardson et al.

LANCET INFECTIOUS DISEASES (2020)

Article Infectious Diseases

Early dynamics of transmission and control of COVID-19: a mathematical modelling study

Adam J. Kucharski et al.

LANCET INFECTIOUS DISEASES (2020)

Letter Critical Care Medicine

SARS-CoV-2 receptor ACE2 gene expression and RAAS inhibitors

Stephen Milne et al.

LANCET RESPIRATORY MEDICINE (2020)

Article Anesthesiology

SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria

Helena Barrasa et al.

ANAESTHESIA CRITICAL CARE & PAIN MEDICINE (2020)

Editorial Material Endocrinology & Metabolism

Commentary: COVID-19 and diabetes mellitus: What we know, how our patients should be treated now, and what should happen next

Angeliki M. Angelidi et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

Article Cardiac & Cardiovascular Systems

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

Shaobo Shi et al.

JAMA CARDIOLOGY (2020)

Article Medicine, General & Internal

Early Predictors of Clinical Deterioration in a Cohort of 239 Patients Hospitalized for Covid-19 Infection in Lombardy, Italy

Maurizio Cecconi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Multidisciplinary Sciences

Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Tommy Tsan-Yuk Lam et al.

NATURE (2020)

Article Multidisciplinary Sciences

Virological assessment of hospitalized patients with COVID-2019

Roman Woelfel et al.

NATURE (2020)

Letter Biochemistry & Molecular Biology

The proximal origin of SARS-CoV-2

Kristian G. Andersen et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Waradon Sungnak et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Temporal dynamics in viral shedding and transmissibility of COVID-19

Xi He et al.

NATURE MEDICINE (2020)

Editorial Material Endocrinology & Metabolism

Endocrine and metabolic link to coronavirus infection

Stefan R. Bornstein et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Article Engineering, Multidisciplinary

Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

Qingxian Cai et al.

ENGINEERING (2020)

Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Covid-19 in Critically Ill Patients in the Seattle Region - Case Series

Pavan K. Bhatraju et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Medicine, General & Internal

Guillain-Barre Syndrome Associated with SARS-CoV-2

Gianpaolo Toscano et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Medicine, General & Internal

SARS-CoV-2 Infection in Children

Xiaoxia Lu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Cardiovascular disease potentially contributes to the progression and poor prognosis of COVID-19

Mingyue Li et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2020)

Letter Radiology, Nuclear Medicine & Medical Imaging

Neurological Dysfunction in Coronavirus Disease-19 (COVID-19)

Arshed Hussain Parry et al.

ACADEMIC RADIOLOGY (2020)

Article Public, Environmental & Occupational Health

Why is There Low Morbidity and Mortality of COVID-19 in Africa?

M. Kariuki Njenga et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2020)

Review Immunology

COVID-19 pathophysiology: A review

Koichi Yuki et al.

CLINICAL IMMUNOLOGY (2020)

Article Infectious Diseases

Viable SARS-CoV-2 in various specimens from COVID-19 patients

Hye Won Jeong et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

Review Oncology

Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence

Elissar Moujaess et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

Letter Respiratory System

Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital

Claudia Stochino et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Editorial Material Respiratory System

COVID-19 and COPD

Janice M. Leung et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Review Oncology

Cancer and COVID-19: Unmasking their ties

A. Addeo et al.

CANCER TREATMENT REVIEWS (2020)

Article Biochemistry & Molecular Biology

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Mehdi Bouhaddou et al.

Editorial Material Immunology

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Yujie Ren et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Article Genetics & Heredity

A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients

Kay Poulton et al.

INTERNATIONAL JOURNAL OF IMMUNOGENETICS (2020)

Article Public, Environmental & Occupational Health

Ethnic and regional variations in hospital mortality from COVID-19 in Brazil: a cross-sectional observational study

Pedro Baqui et al.

LANCET GLOBAL HEALTH (2020)

Review Infectious Diseases

Acute respiratory distress syndrome due to SARS-CoV-2 and Influenza A co-infection in an Italian patient: Mini-review of the literature

Alessandra D'Abramo et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Article Biochemistry & Molecular Biology

HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy

Pierpaolo Correale et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Immunology

Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past

Vibhuti Kumar Shah et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

Immune Response, Inflammation, and the Clinical Spectrum of COVID-19

Luis F. Garcia

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19

Lauren A. Callender et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Medicine, General & Internal

COVID-19: The Potential Treatment of Pulmonary Fibrosis Associated with SARS-CoV-2 Infection

Kacper Lechowicz et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Multidisciplinary Sciences

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

Muhammad Adnan Shereen et al.

JOURNAL OF ADVANCED RESEARCH (2020)

Review Cell Biology

Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report

Huanjie Li et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Medicine, General & Internal

COVID-19 Clinical Characteristics, and Sex-Specific Risk of Mortality: Systematic Review and Meta-Analysis

Mohammad Javad Nasiri et al.

FRONTIERS IN MEDICINE (2020)

Article Pediatrics

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study

Florian Goetzinger et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

Editorial Material Hematology

COVID-19 coagulopathy vs disseminated intravascular coagulation

Marcel Levi

BLOOD ADVANCES (2020)

Article Genetics & Heredity

SARS-CoV-2 genomic variations associated with mortality rate of COVID-19

Yujiro Toyoshima et al.

JOURNAL OF HUMAN GENETICS (2020)

Editorial Material Urology & Nephrology

Java Barb Fish Gallbladder-Induced Acute Kidney Injury and Ischemic Acute Hepatic Failure

Mohammad Rudiansyah et al.

KIDNEY INTERNATIONAL REPORTS (2020)

Letter Infectious Diseases

Beneficial impact of Baricitinib in COVID-19 moderate pneumonia; multicentre study

Fabrizio Cantini et al.

JOURNAL OF INFECTION (2020)

Letter Infectious Diseases

Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2

Feng Wen et al.

JOURNAL OF INFECTION (2020)

Review Urology & Nephrology

Acute Kidney Injury in the 2019 Novel Coronavirus Disease

Jing-Yi Qian et al.

KIDNEY DISEASES (2020)

Review Virology

Influenza and COVID-19 coinfection: Report of six cases and review of the literature

Resat Ozaras et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Letter Respiratory System

Ivermectin Treatment May Improve the Prognosis of Patients With COVID-19

Md. Saiful Islam Khan et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2020)

Article Infectious Diseases

Estimates of the severity of coronavirus disease 2019: a model-based analysis

Robert Verity et al.

LANCET INFECTIOUS DISEASES (2020)

Review Cardiac & Cardiovascular Systems

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

Masataka Nishiga et al.

NATURE REVIEWS CARDIOLOGY (2020)

Review Public, Environmental & Occupational Health

COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions

Ettore Beghi et al.

NEUROEPIDEMIOLOGY (2020)

Letter Pediatrics

SARS-CoV-2 and Streptococcus pneumoniae coinfection as a cause of severe pneumonia in an infant

Montserrat Nieto-Moro et al.

PEDIATRIC PULMONOLOGY (2020)

Review Medicine, General & Internal

COVID-19 and comorbidities: a systematic review and meta-analysis

Morgan Spencer Gold et al.

POSTGRADUATE MEDICINE (2020)

Article Multidisciplinary Sciences

Transplacental transmission of SARS-CoV-2 infection

Alexandre J. Vivanti et al.

NATURE COMMUNICATIONS (2020)

Article Medicine, Research & Experimental

Kinetics of viral load and antibody response in relation to COVID-19 severity

Yanqun Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Infectious Diseases

SARS-CoV-2 detection, viral load and infectivity over the course of an infection

Kieran A. Walsh et al.

JOURNAL OF INFECTION (2020)

Review Medicine, Research & Experimental

The immune system and COVID-19: Friend or foe?

Fereshteh Yazdanpanah et al.

LIFE SCIENCES (2020)

Article Medicine, Research & Experimental

Could aquaporin modulators be employed as prospective drugs for COVID-19 related pulmonary comorbidity?

Lezy Flora Mariajoseph-Antony et al.

MEDICAL HYPOTHESES (2020)

Article Multidisciplinary Sciences

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Ludovico Cantuti-Castelvetri et al.

SCIENCE (2020)

Article Environmental Sciences

The temperature and regional climate effects on communitarian COVID-19 contagion in Mexico throughout phase 1

Fabiola Mendez-Arriaga

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Environmental Sciences

The effects of regional climatic condition on the spread of COVID-19 at global scale

Muhammad Mazhar Iqbal et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Biochemistry & Molecular Biology

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

Nicole A. P. Lieberman et al.

PLOS BIOLOGY (2020)

Article Medicine, General & Internal

Coinfection with SARS-CoV-2 and influenza A virus

Yuki Kondo et al.

BMJ CASE REPORTS (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Jesse Fajnzylber et al.

NATURE COMMUNICATIONS (2020)

Article Endocrinology & Metabolism

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic

Erkan Cure et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

Article Endocrinology & Metabolism

Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States

Bruce Bode et al.

JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Ivermectin as a potential COVID-19 treatment from the pharmacokinetic point of view: antiviral levels are not likely attainable with known dosing regimens

Georgi Momekov et al.

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT (2020)

Article Immunology

Considering how biological sex impacts immune responses and COVID-19 outcomes

Eileen P. Scully et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Genetics & Heredity

Genomic characterization of a novel SARS-CoV-2

Rozhgar A. Khailany et al.

GENE REPORTS (2020)

Letter Immunology

Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China

Xiaojing Wu et al.

EMERGING INFECTIOUS DISEASES (2020)

Letter Obstetrics & Gynecology

Detection of severe acute respiratory syndrome coronavirus 2 in placental and fetal membrane samples

Christina A. Penfield et al.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2020)

Article Endocrinology & Metabolism

Cardiovascular disease and COVID-19

Manish Bansal

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Letter Critical Care Medicine

SARS-CoV-2 viral load in sputum correlates with risk of COVID-19 progression

Xia Yu et al.

CRITICAL CARE (2020)

Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy

Riccardo M. Inciardi et al.

EUROPEAN HEART JOURNAL (2020)

Article Respiratory System

Risk factors for outcomes of acute respiratory distress syndrome patients: a retrospective study

Qingqing Dai et al.

JOURNAL OF THORACIC DISEASE (2019)

Review Microbiology

Human Coronavirus: Host-Pathogen Interaction

To Sing Fung et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 73 (2019)

Review Microbiology

Origin and evolution of pathogenic coronaviruses

Jie Cui et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Review Virology

Bats and Coronaviruses

Arinjay Banerjee et al.

VIRUSES-BASEL (2019)

Article Medicine, General & Internal

Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

C. Fernandez et al.

JOURNAL OF INTERNAL MEDICINE (2018)

Article Cardiac & Cardiovascular Systems

The influence of psychiatric disorders on the course of lung cancer, chronic obstructive pulmonary disease and tuberculosis

Melina Gade Sikjaer et al.

RESPIRATORY MEDICINE (2018)

Review Endocrinology & Metabolism

Inflammaging: a new immune-metabolic viewpoint for age-related diseases

Claudio Franceschi et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Article Virology

Extensive diversity of coronaviruses in bats from China

Xian-Dan Lin et al.

VIROLOGY (2017)

Article Physiology

Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors

Jackye Peretz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)

Editorial Material Public, Environmental & Occupational Health

Cholera and ABO Blood Group: Understanding an Ancient Association

Jason B. Harris et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2016)

Review Immunology

Sex differences in immune responses

Sabra L. Klein et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Cell Biology

Estrogen receptors regulate innate immune cells and signaling pathways

Susan Kovats

CELLULAR IMMUNOLOGY (2015)

Review Respiratory System

The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis

Friedrich Grimminger et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Peripheral Vascular Disease

Blood pressure variability and multiple organ damage in primary hypertension

G. Leoncini et al.

JOURNAL OF HUMAN HYPERTENSION (2013)

Review Cell Biology

Sex differences and estrogen modulation of the cellular immune response after injury

Melanie D. Bird et al.

CELLULAR IMMUNOLOGY (2008)

Review Endocrinology & Metabolism

The complex role of estrogens in inflammation

Rainer H. Straub

ENDOCRINE REVIEWS (2007)

Article Endocrinology & Metabolism

Adipokines and risk of type 2 diabetes in older men

S. Goya Wannamethee et al.

DIABETES CARE (2007)

Article Geriatrics & Gerontology

Comorbidity in older adults: Nosology of impairment, diseases, and conditions

Arun Karlamangla et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2007)

Article Public, Environmental & Occupational Health

Do men have a higher case fatality rate of severe acute respiratory syndrome than women do?

J Karlberg et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2004)

Article Endocrinology & Metabolism

The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men

CJ Malkin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)

Article Medicine, General & Internal

A novel coronavirus associated with severe acute respiratory syndrome

TG Ksiazek et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Review Pathology

Pulmonary fibrosis: Cellular and molecular events

MS Razzaque et al.

PATHOLOGY INTERNATIONAL (2003)

Review Physiology

Mechanisms of estrogen action

S Nilsson et al.

PHYSIOLOGICAL REVIEWS (2001)

Article Education & Educational Research

Men, masculinity, and cancer: Risk-factor behaviors, early detection, and psychosocial adaptation

DR Nicholas

JOURNAL OF AMERICAN COLLEGE HEALTH (2000)

Article Education & Educational Research

Why do men get more heart disease than women? An international perspective

G Weidner

JOURNAL OF AMERICAN COLLEGE HEALTH (2000)