Journal
ELIFE
Volume 10, Issue -, Pages -Publisher
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.67600
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Funding
- National Natural Science Foundation of China [91432302, 82072099, 31620103905]
- Chinese Academy of Sciences [XDB32030200, QYZDJ-SSW-SMC019]
- Key-Area Research and Development Program of Guangdong Province [2018B030333001]
- National Science Foundation [SMA-1542848]
- Beijing Advanced Discipline Fund
- Beijing Municipal Science and Technology Commission [Z161100000216139, Z171100000117002]
- Chinese Academy of Sciences
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Research has shown that the IPL in the human cerebral cortex exhibits structural and connectional asymmetries in different primate species, with these asymmetries potentially contributing to hemispheric specialization in the human brain.
The inferior parietal lobule (IPL) is one of the most expanded cortical regions in humans relative to other primates. It is also among the most structurally and functionally asymmetric regions in the human cerebral cortex. Whether the structural and connectional asymmetries of IPL subdivisions differ across primate species and how this relates to functional asymmetries remain unclear. We identified IPL subregions that exhibited positive allometric in both hemispheres, scaling across rhesus macaque monkeys, chimpanzees, and humans. The patterns of IPL subregions asymmetry were similar in chimpanzees and humans, but no IPL asymmetries were evident in macaques. Among the comparative sample of primates, humans showed the most widespread asymmetric connections in the frontal, parietal, and temporal cortices, constituting leftward asymmetric networks that may provide an anatomical basis for language and tool use. Unique human asymmetric connectivity between the IPL and primary motor cortex might be related to handedness. These findings suggest that structural and connectional asymmetries may underlie hemispheric specialization of the human brain.
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