HIV-1 INFECTION You can keep your coat on

Article Biochemistry & Molecular Biology

Factors that mold the nuclear landscape of HIV-1 integration

Gregory J. Bedwell et al.

Summary: Integration of retroviral reverse transcripts into the chromatin of host cells is crucial for virus replication, with HIV-1 efficiently infecting interphase cells and targeting specific chromosomal sites for integration. The interactions between viral and host factors, as well as the nuclear landscape, play key roles in facilitating HIV-1 integration and influencing the establishment of active versus latent virus infection.

NUCLEIC ACIDS RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Cone-shaped HIV-1 capsids are transported through intact nuclear pores

Vojtech Zila et al.

Summary: The study reveals that the diameter of the nuclear pore complex in infected T cells is sufficient for the import of intact, cone-shaped capsids, with uncoating occurring by breaking the capsid open after nuclear import rather than disassembly into individual subunits. This visualization of a key step in HIV-1 replication enhances our understanding of the viral life cycle.

CELL (2021)

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Article Biology

HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

Thorsten G. Mueller et al.

Summary: The study found that uncoating of HIV-1 occurs through physical disruption in the cell nucleus rather than cooperative disassembly of the CA-lattice, followed by physical separation from the pre-integration complex.

ELIFE (2021)

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Article Multidisciplinary Sciences