Journal
ELIFE
Volume 10, Issue -, Pages -Publisher
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.72409
Keywords
Myxococcus xanthus; predation; tad pilus; motility; Other
Categories
Funding
- Centre National de la Recherche Scientifique [2019 CNRS 80]
- Ministere de l'Education Nationale, de la Formation professionnelle, de l'Enseignement Superieur et de la Recherche Scientifique
Ask authors/readers for more resources
Myxococcus xanthus, a soil bacterium, preys collectively on prey colonies using A-motility and contact-dependent killing as central predatory mechanisms. The newly discovered Kil-like systems form a new class of Tad-like machineries in predatory bacteria, with a conserved function in predator-prey interactions. This study also reveals a novel cell-cell interaction function for bacterial pili-like assemblages.
Myxococcus xanthus, a soil bacterium, predates collectively using motility to invade prey colonies. Prey lysis is mostly thought to rely on secreted factors, cocktails of antibiotics and enzymes, and direct contact with Myxococcus cells. In this study, we show that on surfaces the coupling of A-motility and contact-dependent killing is the central predatory mechanism driving effective prey colony invasion and consumption. At the molecular level, contact-dependent killing involves a newly discovered type IV filament-like machinery (Kil) that both promotes motility arrest and prey cell plasmolysis. In this process, Kil proteins assemble at the predator-prey contact site, suggesting that they allow tight contact with prey cells for their intoxication. Kil-like systems form a new class of Tad-like machineries in predatory bacteria, suggesting a conserved function in predator-prey interactions. This study further reveals a novel cell-cell interaction function for bacterial pili-like assemblages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available