4.8 Article

Understanding the evolution of multiple drug resistance in structured populations

Journal

ELIFE
Volume 10, Issue -, Pages -

Publisher

eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.65645

Keywords

-

Categories

Funding

  1. NSERC-CRSNG postdoctoral fellowship
  2. Agence Nationale de la Recherche [ANR-17-CE35-0012]
  3. Agence Nationale de la Recherche (ANR) [ANR-17-CE35-0012] Funding Source: Agence Nationale de la Recherche (ANR)

Ask authors/readers for more resources

Studying the evolution of multidrug resistance (MDR) by focusing on the dynamical equations for linkage disequilibrium (LD) can simplify calculations, generate more insight, and provide a unified framework for understanding the role of population structure.
The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood. Here, we argue that studying MDR evolution by focusing upon the dynamical equations for linkage disequilibrium (LD) can greatly simplify the calculations, generate more insight, and provide a unified framework for understanding the role of population structure. We demonstrate how a general epidemiological model of MDR evolution can be recast in terms of the LD equations. These equations reveal how the different forces generating and propagating LD operate in a dynamical setting at both the population and metapopulation levels. We then apply these insights to show how the LD perspective: (i) explains equilibrium patterns of MDR, (ii) provides a simple interpretative framework for transient evolutionary dynamics, and (iii) can be used to assess the consequences of different drug prescription strategies for MDR evolution.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available