Journal
CHINESE MEDICINE
Volume 16, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13020-021-00469-4
Keywords
TCM; NAFLD; Single herb; TCM compound; Mechanism
Funding
- National Natural Science Foundation of China [82073907]
- Shanghai Science and Technology Innovation Action Plan [20ZR1470100, 20S11902700]
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This article summarizes the advantages and obstacles of traditional Chinese medicine in the treatment of nonalcoholic fatty liver disease, and discusses the combined mechanism of herbs in TCM compounds.
Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM's holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease. However, the multi-compounds and multi-targets are big obstacle for the study of TCM. Here, we summarize the pharmacological actions of active ingredients from frequently used single herbs in TCM compounds. The combined mechanism of herbs in TCM compounds are further discussed to explore their comprehensive effects on NAFLD. This article aims to summarize multiple functions and find the common ground for TCM treatment on NAFLD, thus providing enrichment to the scientific connotation of TCM theories and promotes the exploration of TCM therapies on NAFLD.
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