4.2 Article

Development, Characterization, and Evaluation of SLN-Loaded Thermoresponsive Hydrogel System of Topotecan as Biological Macromolecule for Colorectal Delivery

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Comparative study between high-pressure homogenisation and Shirasu porous glass membrane technique in sildenafil base-loaded solid SNEDDS: Effects on physicochemical properties and in vivo characteristics

Jung Suk Kim et al.

Summary: This study compared the effects of two emulsification techniques on solid SNEDDS, showing that solid SNEDDS subjected to HPH had better drug solubility and oral bioavailability compared to SB powder and SPG. Both emulsification techniques were able to convert the drug crystalline state into an amorphous state.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

Development, in vitro and in vivo evaluation of miltefosine loaded nanostructured lipid carriers for the treatment of Cutaneous Leishmaniasis

Anam Sajjad Khan et al.

Summary: The study aimed to enhance the efficacy and reduce the toxic effects of MTF in treating leishmaniasis by loading it into NLCs. The optimized NLCs showed good drug release, significantly increased anti-leishmanial efficacy, and better safety profile compared to MTF solution. The passive targeting ability of MTF-loaded NLCs was confirmed through macrophage uptake study.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium

Bhupendra Raj Giri et al.

Summary: Surface-attached solid dispersion (SASD) formulations were developed to enhance the solubility, bioavailability, and photostability of methotrexate (MTX). The spray-dried MTX-loaded SASD formulation improved the oral bioavailability of MTX without significant deterioration of its photochemical stability.

PHARMACEUTICS (2021)

Article Chemistry, Medicinal

Macrophage targeting with the novel carbopol-based miltefosine-loaded transfersomal gel for the treatment of cutaneous leishmaniasis: in vitro and in vivo analyses

Sibgha Batool et al.

Summary: The study successfully developed a novel carbopol-based miltefosine-loaded transfersomal gel (HePCTG) for the treatment of cutaneous leishmaniasis. Experimental results demonstrated that HePCTG exhibited favorable drug release properties, good targeting effect on infected macrophages, and significant anti-leishmanial activity.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2021)

Article Polymer Science

Particle and Gel Characterization of Irinotecan-Loaded Double-Reverse Thermosensitive Hydrogel

Fakhar Ud Din et al.

Summary: The irinotecan-loaded double-reverse thermosensitive hydrogel is a promising system for rectal administration, with optimised properties for drug encapsulation and gel formation. The use of solid lipid nanoparticles and thermosensitive hydrogels in combination shows potential for efficient drug delivery.

POLYMERS (2021)

Review Biotechnology & Applied Microbiology

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

Humzah Jamshaid et al.

Summary: Nano-technology plays a significant role in the treatment and prevention of Leishmaniasis, overcoming various obstacles in traditional therapies through the design of nano-drug delivery systems and nano-vaccines. This innovative approach has improved the efficacy and safety of drugs, offering a promising solution for controlling the disease and its complications.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Pharmacology & Pharmacy

Preparation, in-vitro and in-vivo evaluation of Rifampicin and Vancomycin Co-loaded transfersomal gel for the treatment of cutaneous leishmaniasis

Muhammad Waqas Salim et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

Article Pharmacology & Pharmacy

Development and characterisation of levosulpiride-loaded suppositories with improved bioavailability in vivo

Fakhar-ud-Din et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2019)

Article Pharmacology & Pharmacy

Development, in-vitro and in-vivo evaluation of ezetimibe-loaded solid lipid nanoparticles and their comparison with marketed product

Fakhar Ud Din et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

Article Pharmacology & Pharmacy

Simvastatin-loaded solid lipid nanoparticles for enhanced anti-hyperlipidemic activity in hyperlipidemia animal model

Syed Zaki Husain Rizvi et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Review Nanoscience & Nanotechnology

Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

Fakhara Sabir et al.

JOURNAL OF NANOMATERIALS (2019)

Article Oncology

Enhanced Anti-Cancer Capability of Ellagic Acid Using Solid Lipid Nanoparticles (SLNs)

Hamed Hajipour et al.

INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (2018)

Article Pharmacology & Pharmacy

Topotecan-loaded lipid nanoparticles as a viable tool for the topical treatment of skin cancers

Joao Helio Venancio et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2017)

Review Nanoscience & Nanotechnology

Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery

Maria Mir et al.

NANOSCALE RESEARCH LETTERS (2017)

Review Nanoscience & Nanotechnology

Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery

Maria Mir et al.

NANOSCALE RESEARCH LETTERS (2017)

Article Biochemistry & Molecular Biology

Development and evaluation of topotecan loaded solid lipid nanoparticles: A study in cervical cancer cell lines

Zhao-jie Chen et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2016)

Article Pharmacology & Pharmacy

Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate

Urszula Posadowska et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Article Materials Science, Biomaterials

Systemic delivery of axitinib with nanohybrid liposomal nanoparticles inhibits hypoxic tumor growth

Ju Yeon Choi et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

Article Chemistry, Multidisciplinary

Polypeptide-based Micelles for Delivery of Irinotecan: Physicochemical and In vivo Characterization

Thiruganesh Ramasamy et al.

PHARMACEUTICAL RESEARCH (2015)

Article Pharmacology & Pharmacy

Development of novel fast-dissolving tacrolimus solid dispersion-loaded prolonged release tablet

Jung Hyun Cho et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

Article Pharmacology & Pharmacy

Preparation and evaluation of mesalamine collagen in situ rectal gel: A novel therapeutic approach for treating ulcerative colitis

Satiesh Kumar Ramadass et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

Article Biochemistry & Molecular Biology

Acupuncture ameliorated skeletal muscle atrophy induced by hindlimb suspension in mice

Akiko Onda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

Injectable Thermally Responsive Mucoadhesive Gel for Sustained Protein Delivery

Laura Mayol et al.

BIOMACROMOLECULES (2011)

Article Pharmacology & Pharmacy

The physical state of lipid nanoparticles influences their effect on in vitro cell viability

Silvia Petersen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)

Article Pharmacology & Pharmacy

Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release

L. G. Souza et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)

Article Chemistry, Multidisciplinary

Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles

HouLi Li et al.

JOURNAL OF CONTROLLED RELEASE (2009)

Article Chemistry, Medicinal

Preparation, optimization, and characterization of topotecan loaded PEGylated liposomes using factorial design

Amir Masoud Vali et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2008)

Article Engineering, Biomedical

Temporary vascular occlusion with poloxamer 407

J Raymond et al.

BIOMATERIALS (2004)

Article Pharmacology & Pharmacy

Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol

CS Yong et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2004)

Review Pharmacology & Pharmacy

Solid lipid nanoparticles (SLN) for controlled drug delivery -: a review of the state of the art

RH Müller et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2000)